LQT10: Difference between revisions
Jump to navigation
Jump to search
(Created page with "__NOTOC__ {{Long QT Syndrome}} {{CMG}} ==Overview== ==References== {{Reflist|2}} Category:Cardiology Category:Electrophysiology") |
No edit summary |
||
| Line 5: | Line 5: | ||
==Overview== | ==Overview== | ||
==LQT10== | |||
{| class="wikitable" | |||
| '''Type''' || '''OMIM''' || '''Mutation''' | |||
|- | |||
| [[LQT10]] || || [[SCN4B]] || | |||
|} | |||
This novel susceptibility gene for LQT is ''SCN4B'' encoding the protein Na<sub>V</sub>β4, an auxiliary [[subunit]] to the pore-forming Na<sub>V</sub>1.5 (gene: ''SCN5A'') subunit of the [[voltage-gated sodium channel]] of the heart. The mutation leads to a positive shift in inactivation of the sodium current, thus increasing sodium current. Only one mutation in one patient has so far been found. | |||
==References== | ==References== | ||
Revision as of 17:35, 7 October 2012
|
Long QT Syndrome Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
LQT10 On the Web |
|
American Roentgen Ray Society Images of LQT10 |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]
Overview
LQT10
| Type | OMIM | Mutation | |
| LQT10 | SCN4B |
This novel susceptibility gene for LQT is SCN4B encoding the protein NaVβ4, an auxiliary subunit to the pore-forming NaV1.5 (gene: SCN5A) subunit of the voltage-gated sodium channel of the heart. The mutation leads to a positive shift in inactivation of the sodium current, thus increasing sodium current. Only one mutation in one patient has so far been found.