Brugada syndrome risk factors: Difference between revisions
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==Risk Factors: Agents and Scenarios that Provoke the Brugada Syndrome Pattern== | ==Risk Factors: Agents and Scenarios that Provoke the Brugada Syndrome Pattern== | ||
The electrocardiographic findings of Brugada syndrome are often concealed, but can be unmasked or modulated by a number of drugs and pathophysiological states including: | The electrocardiographic findings of Brugada syndrome are often concealed, but can be unmasked or modulated by a number of drugs and pathophysiological states including (in alphabetical order): | ||
*A combination of [[glucose]] and [[insulin]] | *A combination of [[glucose]] and [[insulin]] | ||
*[[Ajmaline]] (a diagnostic test agent) | *[[Ajmaline]] (a diagnostic test agent) | ||
*[[α-adrenergic agonists]] | |||
*[[β-adrenergic blockers]] | |||
*[[Cocaine]] | *[[Cocaine]] | ||
*[[Fever]] | *[[Fever]] | ||
Line 23: | Line 25: | ||
*[[Tricyclic antidepressants]] | *[[Tricyclic antidepressants]] | ||
*[[Vagotonic agents]] that mimic sleep | *[[Vagotonic agents]] that mimic sleep | ||
==Risk Statification== | ==Risk Statification== |
Revision as of 01:34, 14 October 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Risk Factors: Agents and Scenarios that Provoke the Brugada Syndrome Pattern
The electrocardiographic findings of Brugada syndrome are often concealed, but can be unmasked or modulated by a number of drugs and pathophysiological states including (in alphabetical order):
- A combination of glucose and insulin
- Ajmaline (a diagnostic test agent)
- α-adrenergic agonists
- β-adrenergic blockers
- Cocaine
- Fever
- Flecainide (a diagnostic test agent)
- Hypercalcemia
- Hyperkalemia
- Hypokalemia
- In large studies, a family history of sudden cardiac death among patients with Brugada syndrome does not appear to be a risk factor for sudden cardiac death in siblings.
- Procainamide (a diagnostic test agent)
- Propranolol intoxication
- Sodium channel blockers (a diagnostic test agent)
- Tetracyclic antidepressants
- Tricyclic antidepressants
- Vagotonic agents that mimic sleep
Risk Statification
- Patients with syncope and an abnormal Type 1 ECG are at higher risk
- Asymptomatic patients at risk can be identified
- Presence of spontaneous Type 1 ST-segment elevation
- Characteristics of the S wave
- Presence of late potentials
- Inducibility of VT/VF using PES is controversial as a risk factor.