Brugada syndrome risk factors: Difference between revisions
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==Risk Statification== | ==Risk Statification== | ||
* Patients with syncope and an abnormal Type 1 ECG are at higher risk | * Patients with [[syncope]] and an abnormal Type 1 ECG are at higher risk | ||
* Asymptomatic patients at risk can be identified | * Asymptomatic patients at risk can be identified | ||
** Presence of spontaneous Type 1 ST-segment elevation | ** Presence of spontaneous Type 1 [[ST-segment elevation]] | ||
** Characteristics of the S wave | ** Characteristics of the S wave | ||
** Presence of late potentials | ** Presence of late potentials | ||
** Inducibility of VT/VF using PES is controversial as a risk factor. | ** Inducibility of [[VT]]/[[VF]] using PES is controversial as a risk factor. | ||
==References== | ==References== |
Revision as of 01:36, 14 October 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Risk Factors: Agents and Scenarios that Provoke the Brugada Syndrome Pattern
The electrocardiographic findings of Brugada syndrome are often concealed, but can be unmasked or modulated by a number of drugs and pathophysiological states including (in alphabetical order)[1]:
- A combination of glucose and insulin
- Ajmaline (a diagnostic test agent)
- α-adrenergic agonists
- β-adrenergic blockers
- Cocaine
- Fever
- Flecainide (a diagnostic test agent)
- Hypercalcemia
- Hyperkalemia
- Hypokalemia
- In large studies, a family history of sudden cardiac death among patients with Brugada syndrome does not appear to be a risk factor for sudden cardiac death in siblings.
- Procainamide (a diagnostic test agent)
- Propranolol intoxication
- Sodium channel blockers (a diagnostic test agent)
- Tetracyclic antidepressants
- Tricyclic antidepressants
- Vagotonic agents that mimic sleep
Risk Statification
- Patients with syncope and an abnormal Type 1 ECG are at higher risk
- Asymptomatic patients at risk can be identified
- Presence of spontaneous Type 1 ST-segment elevation
- Characteristics of the S wave
- Presence of late potentials
- Inducibility of VT/VF using PES is controversial as a risk factor.
References
- ↑ Antzelevitch C, Brugada P, Borggrefe M, Brugada J, Brugada R, Corrado D, Gussak I, LeMarec H, Nademanee K, Perez Riera AR, Shimizu W, Schulze-Bahr E, Tan H, Wilde A (2005). "Brugada syndrome: report of the second consensus conference". Heart Rhythm : the Official Journal of the Heart Rhythm Society. 2 (4): 429–40. PMID 15898165. Unknown parameter
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