Cardiomegaly causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Causes

Causes by Organ System

Cardiovascular	ALCAPA, Aortic regurgitation, Aortic stenosis, Arrhythmia, Atrial septal defect, Cardiac myxoma , Chronic thromboebolic pulmonary hypertension, Coarctation of aorta, Congenital heart disease, Congestive heart failure, Cor pulmonale, Diabetes, Eisenmenger's syndrome, Endocardial fibroelastosis, Endocarditis, Heart attack, Hypertension, Idiopathic dilated cardiomyopathy, Ischaemic heart disease, Kawasaki disease, Low output cardiac failure, Mitral regurgitation, Myocarditis, Myocarial infarction, Pericardial effusion, Pericarditis, Peripartum heart failure, Polyarteritis nodosa, Pulmonary hypertension, Pulmonary stenosis, Rheumatic fever, Tricuspid regurgitation, Valvular heart disease, Ventricular aneurysm, Ventricular septal defect, Cardiofaciocutaneous syndrome, Carvajal-Huerta syndrome, Familial hypertrophic cardiomyopathy , Naxos disease, X-linked dilated cardiomyopathy, Peripartum cardiomyopathy, Carcinoid heart disease, Salih myopathy, Costello syndrome, Hypertrichotic osteochondrodysplasia, Epicardial fat pad
Chemical / poisoning	Cobalt, Ethylene glycol
Dermatologic	Hypertrichotic osteochondrodysplasia, Multiple lentigines syndrome, Cardiofaciocutaneous syndrome, Carvajal-Huerta syndrome, Naxos disease, Costello syndrome
Drug Side Effect	Atenolol, Carfilzomib, Certolizumab pegol, Disopyramide, Dronedarone, Epirubicin, Ethanol, Imatinib mesylate, Lapatinib ditosylate, Phenylbutazone, Procainamide, Propranolol, Rosiglitazone, Sunitinib malate, Trastuzumab, Troglitazone, Verapamil
Ear Nose Throat	No underlying causes
Endocrine	Acromegaly, Cushing syndrome, Hyperthyroidism, Hypothyroidism, Carcinoid heart disease, Hyperparathyroidism
Environmental	No underlying causes
Gastroenterologic	Mulibrey nanism
Genetic	1p36 deletion syndrome, Alstrom syndrome, Barth syndrome, Becker muscular dystrophy, Beckwith–Wiedemann syndrome, Cardiofaciocutaneous syndrome, Carnitine palmitoyltransferase deficiency, Carvajal-Huerta syndrome, Congenital generalized lipodystrophy , Costello syndrome, Danon disease, Desmin-related myofibrillar myopathy, Duchenne muscular dystrophy, Emery-Dreifuss muscular dystrophy, X-linked, Ethanolamine kinase deficiency, Fabry disease, Familial hypertrophic cardiomyopathy , Friedreich ataxia, Fucosidosis, Gaucher disease type IIIC, Glycogenosis type 2, Glycogenosis type 2b, Hemochromatosis, Hereditary spherocytosis, Hunter syndrome, Hypertrichotic osteochondrodysplasia, Infantile sialic acid storage disorder, Isobutyryl-CoA dehydrogenase deficiency, Laing distal myopathy, Long-chain acyl-CoA dehydrogenase deficiency, Malonyl-CoA decarboxylase deficiency, McLeod neuroacanthocytosis syndrome, MELAS, Morquio syndrome, Mucopolysaccharidosis type IIIB, Mulibrey nanism, Multiple lentigines syndrome, Myotonic dystrophy, Naxos disease, Noonan syndrome, Refsum disease, Salih myopathy, Sandhoff disease, Singleton-Merten syndrome, Tay-Sachs' disease, Thalassemia, Very long-chain acyl-CoA dehydrogenase deficiency, X-linked dilated cardiomyopathy, Yunis-Varon syndrome, Hurler syndrome, Sickle cell disease
Hematologic	Anemia, Hemochromatosis, Hereditary spherocytosis, McLeod neuroacanthocytosis syndrome, Thalassemia, Sickle cell disease
Iatrogenic	Water overload
Infectious Disease	Chagas disease, Rheumatic fever
Musculoskeletal / Ortho	Becker muscular dystrophy, Desmin-related myofibrillar myopathy, Duchenne muscular dystrophy, Emery-Dreifuss muscular dystrophy, X-linked, Laing distal myopathy, Mulibrey nanism, Myotonic dystrophy, Salih myopathy, Yunis-Varon syndrome, Hypertrichotic osteochondrodysplasia
Neurologic	Costello syndrome, Friedreich ataxia, Mulibrey nanism
Nutritional / Metabolic	Beri-beri, Kwashiorkor, Selenium deficiency, Alstrom syndrome, Barth syndrome, Carnitine palmitoyltransferase deficiency, Ethanolamine kinase deficiency, Fabry disease, Fucosidosis, Gaucher disease type IIIC, Glycogenosis type 2, Glycogenosis type 2b, Hunter syndrome, Infantile sialic acid storage disorder, Isobutyryl-CoA dehydrogenase deficiency, Long-chain acyl-CoA dehydrogenase deficiency, Malonyl-CoA decarboxylase deficiency, Morquio syndrome, Mucopolysaccharidosis type IIIB, Refsum disease, Sandhoff disease, Tay-Sachs' disease, Very long-chain acyl-CoA dehydrogenase deficiency
Obstetric/Gynecologic	Hemolytic disease of the newborn, Infants born to diabetic mothers, Peripartum cardiomyopathy, Peripartum heart failure
Oncologic	Carcinoid heart disease, Pheochromocytoma, Cardiac myxoma
Opthalmologic	Mulibrey nanism, Alstrom syndrome
Overdose / Toxicity	Atenolol, Carfilzomib, Certolizumab pegol, Disopyramide, Dronedarone, Epirubicin, Ethanol, Imatinib mesylate, Lapatinib ditosylate, Phenylbutazone, Procainamide, Propranolol, Rosiglitazone, Sunitinib malate, Trastuzumab, Troglitazone, Verapamil
Psychiatric	No underlying causes
Pulmonary	Coal worker pneumoconiosis, Cor pulmonale, Pulmonary hypertension, COPD
Renal / Electrolyte	Renal failure
Rheum / Immune / Allergy	Amyloidosis, Systemic lupus erythematosus
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Dental	No underlying causes
Miscellaneous	Alcoholism

Causes in Alphabetical Order

1p36 deletion syndrome Acromegaly ALCAPA Alcoholism Alstrom syndrome Amyloidosis Anemia Aortic regurgitation Aortic stenosis Arrhythmia Atenolol Atrial septal defect Barth syndrome Becker muscular dystrophy Beckwith–Wiedemann syndrome Beri-beri Carcinoid heart disease Cardiac myxoma Cardiofaciocutaneous syndrome Carfilzomib Carnitine palmitoyltransferase deficiency Carvajal-Huerta syndrome Certolizumab pegol Chagas disease Chronic thromboebolic pulmonary hypertension Coal worker pneumoconiosis Coarctation of aorta Cobalt Congenital generalized lipodystrophy Congenital heart disease Congestive heart failure COPD Cor pulmonale Costello syndrome Cushing syndrome Danon disease Desmin-related myofibrillar myopathy Diabetes Disopyramide Dronedarone Duchenne muscular dystrophy Eisenmenger's syndrome

Emery-Dreifuss muscular dystrophy, X-linked Endocardial fibroelastosis Endocarditis Epicardial fat pad Epirubicin Ethanol Ethanolamine kinase deficiency Ethylene glycol Fabry disease Familial hypertrophic cardiomyopathy Friedreich ataxia Fucosidosis Gaucher disease type IIIC Glycogenosis type 2 Glycogenosis type 2b Heart attack Hemochromatosis Hemolytic disease of the newborn Hereditary spherocytosis Hunter syndrome Hurler's syndrome Hyperparathyroidism Hypertension Hyperthyroidism Hypertrichotic osteochondrodysplasia Hypothyroidism Idiopathic dilated cardiomyopathy Imatinib mesylate Infantile sialic acid storage disorder Infants born to diabetic mothers Ischaemic heart disease Isobutyryl-CoA dehydrogenase deficiency Kawasaki disease Kwashiorkor Laing distal myopathy Lapatinib ditosylate Long-chain acyl-CoA dehydrogenase deficiency Low output cardiac failure Malonyl-CoA decarboxylase deficiency McLeod neuroacanthocytosis syndrome MELAS Mitral regurgitation Morquio syndrome Mucopolysaccharidosis type IIIB

Mulibrey nanism Multiple lentigines syndrome Myocarditis Myocarial infarction Myotonic dystrophy Naxos disease Noonan syndrome Pericardial effusion Pericarditis Peripartum cardiomyopathy Peripartum heart failure Phenylbutazone Pheochromocytoma Polyarteritis nodosa Procainamide Propranolol Pulmonary hypertension Pulmonary stenosis Refsum disease Renal failure Rheumatic fever Rosiglitazone Salih myopathy Sandhoff disease Selenium deficiency Sickle cell disease Singleton-Merten syndrome Sunitinib malate Systemic lupus erythematosus Tay-Sachs' disease Thalassemia Trastuzumab Tricuspid regurgitation Troglitazone Valvular heart disease Ventricular aneurysm Ventricular septal defect Verapamil Very long-chain acyl-CoA dehydrogenase deficiency Water overload X-linked dilated cardiomyopathy Yunis-Varon syndrome