Diastolic dysfunction causes

Diastolic dysfunction Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Assistant Editor(s)-in-Chief: Rim Halaby

Overview

Diastolic dysfunction is the mechanical abnormality of the heart to properly relax and fill with blood during diastole. Several medical conditions may lead to diastolic dysfunction and they include impaired myocardial relaxation, increased myocardial stiffness and extrinsic constraint on the heart.

Causes

In alphabetical order:

• Amyloidosis
• Aortic stenosis
• Constrictive pericarditis
• Diabetes
• Effusive-constrictive pericarditis
• Glycogen storage disease
• Hemochromatosis
• Hypereosinophilic syndrome
• Hypertrophic heart diseases(for example, as seen in hypertension)
• Hypertrophic obstructive cardiomyopathy (HOCM)
• Infiltrative diseases ( for example, amyloidosis)
• Ischemia
• Mitral stenosis
• Myocardial infarction and scar
• Pericardial effusion
• Restrictive cardiomyopathy
• Sarcoidosis
• Systolic dysfunction

Differential Diagnosis of Diastolic Dysfunction

Cardiovascular	No underlying causes
Cardiovascular	Aortic stenosis; Constrictive pericarditis; Effusive-constrictive pericarditis; Hypertrophic heart diseases; Hypertrophic obstructive cardiomyopathy (HOCM); Ischemia; Mitral stenosis; Myocardial infarction and scar; Pericardial effusion; Restrictive cardiomyopathy; Systolic dysfunction
Chemical / poisoning	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	No underlying causes
Ear Nose Throat	No underlying causes
Endocrine	Diabetes
Environmental	No underlying causes
Gastroenterologic	No underlying causes
Genetic	Hypertrophic obstructive cardiomyopathy (HOCM)
Hematologic	No underlying causes
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal / Ortho	No underlying causes
Neurologic	No underlying causes
Nutritional / Metabolic	Glycogen storage disease; Hemochromatosis; Amyloidosis
Obstetric/Gynecologic	No underlying causes
Oncologic	No underlying causes
Opthalmologic	No underlying causes
Overdose / Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	Sarcoidosis
Renal / Electrolyte	No underlying causes
Rheum / Immune / Allergy	Hypereosinophilic syndrome; Sarcoidosis
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	No underlying causes