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|MainCategory=Genitourinary
|MainCategory=Genitourinary
|SubCategory=Microbiology
|SubCategory=Microbiology
|Prompt=A 34-year-old man comes to the health center with fears that he has contracted a venereal disease. He nervously shows you an ulcerated lesion on the shaft of his penis and states that it has been present for over 1 week. On physical exam, the man is afebrile and except for mild lymphadenopathy in the neck, has a nontender ulcer on his penis measuring 1.5 x 1 x 0.5 cm. Laboratory testing shows him to be VDRL positive. What is the next step in diagnosis?  
|Prompt=A 34-year-old man comes to the health center with fears that he has contracted a venereal disease. He nervously shows you an ulcerated lesion on the shaft of his penis and states that it has been present for over 1 week. On physical exam, the man is afebrile and except for mild lymphadenopathy in the neck, has a nontender ulcer on his penis measuring 1.5 x 1 x 0.5 cm. Laboratory testing shows him to be VDRL positive. What is the next step in diagnosis?
|Answer=Repeat VDRL in 1 week.,Obtain RPR for confirmation.,Obtain DS-DNA serology.,Proceed with treatment of the suspected disease.  
|AnswerA=Repeat VDRL in 1 week.
|RightAnswer=Obtain a fluorescent treponemal antibody absorption (FTA-ABS).
|AnswerB=Obtain RPR for confirmation.
|Explanation=This patient likely has syphilis by clinical presentation and positive VDRL testing; however, correct diagnosis should be made with confirmation with treponemal testing (either FTA-ABS or FTA-TP) before treatment since VDRL and RPR may be turned falsely positive by some autoimmune diseases.  
|AnswerC=Obtain DS-DNA serology.
|AnswerD=Obtain a fluorescent treponemal antibody absorption (FTA-ABS).
|AnswerE=Proceed with treatment of the suspected disease.
|RightAnswer=D
|Explanation=This patient likely has syphilis by clinical presentation and positive VDRL testing; however, correct diagnosis should be made with confirmation with treponemal testing (either FTA-ABS or FTA-TP) before treatment since VDRL and RPR may be turned falsely positive by some autoimmune diseases.
|Answer=Repeat VDRL in 1 week.,Obtain RPR for confirmation.,Obtain DS-DNA serology.,Proceed with treatment of the suspected disease.
}}
}}

Revision as of 17:03, 22 October 2012

 
Author PageAuthor::
Exam Type ExamType::
Main Category MainCategory::Genitourinary
Sub Category SubCategory::Microbiology
Prompt [[Prompt::A 34-year-old man comes to the health center with fears that he has contracted a venereal disease. He nervously shows you an ulcerated lesion on the shaft of his penis and states that it has been present for over 1 week. On physical exam, the man is afebrile and except for mild lymphadenopathy in the neck, has a nontender ulcer on his penis measuring 1.5 x 1 x 0.5 cm. Laboratory testing shows him to be VDRL positive. What is the next step in diagnosis?]]
Answer A AnswerA::Repeat VDRL in 1 week.
Answer A Explanation AnswerAExp::
Answer B AnswerB::Obtain RPR for confirmation.
Answer B Explanation AnswerBExp::
Answer C AnswerC::Obtain DS-DNA serology.
Answer C Explanation AnswerCExp::
Answer D AnswerD::Obtain a fluorescent treponemal antibody absorption (FTA-ABS).
Answer D Explanation AnswerDExp::
Answer E AnswerE::Proceed with treatment of the suspected disease.
Answer E Explanation AnswerEExp::
Right Answer RightAnswer::D
Explanation [[Explanation::This patient likely has syphilis by clinical presentation and positive VDRL testing; however, correct diagnosis should be made with confirmation with treponemal testing (either FTA-ABS or FTA-TP) before treatment since VDRL and RPR may be turned falsely positive by some autoimmune diseases.

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