Dermatomyositis pathophysiology: Difference between revisions
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
==Pathophysiology== | ==Pathophysiology== | ||
On the muscle biopsy, there are two classic microscopic findings of dermatomyositis. They are: | |||
* A mixed [[B-cell|B-]] and [[T-cell]] perivascular inflammatory infiltrate | * A mixed [[B-cell|B-]] and [[T-cell]] perivascular inflammatory infiltrate | ||
* Perifascicular muscle fiber atrophy | * Perifascicular muscle fiber atrophy | ||
| Line 16: | Line 16: | ||
===Microscopic findings=== | ===Microscopic findings=== | ||
Cross sections of muscle reveal muscle fascicles with small, shrunken polygonal muscle fibers on the periphery of a fascicle surrounding central muscle fibers of normal, uniform size. | |||
Cross sections of muscle reveal muscle fascicles with small, shrunken polygonal muscle fibers on the periphery of a fascicle surrounding central muscle fibers of normal, uniform size. | |||
Aggregates of mature [[lymphocytes]] with small, dark nuclei and scant cytoplasm are seen surrounding vessels. Other inflammatory cells are distinctly uncommon. [[Immunohistochemistry]] can be used to demonstrate that both B- and T-cells are present in approximately equal numbers.<ref>Benveniste O, Squier W, Boyer O, Hilton-Jones D, Herson S. ''Presse Med''. '''2004''' Nov 20;33(20):1444-50. PMID: 15611679</ref> <ref>Nirmalananthan N, Holton JL, Hanna MG. Is it really myositis? A consideration of the differential diagnosis. ''Curr Opin Rheumatol''. '''2004''' Nov;16(6):684-91.</ref> | Aggregates of mature [[lymphocytes]] with small, dark nuclei and scant cytoplasm are seen surrounding vessels. Other inflammatory cells are distinctly uncommon. [[Immunohistochemistry]] can be used to demonstrate that both B- and T-cells are present in approximately equal numbers.<ref>Benveniste O, Squier W, Boyer O, Hilton-Jones D, Herson S. ''Presse Med''. '''2004''' Nov 20;33(20):1444-50. PMID: 15611679</ref> <ref>Nirmalananthan N, Holton JL, Hanna MG. Is it really myositis? A consideration of the differential diagnosis. ''Curr Opin Rheumatol''. '''2004''' Nov;16(6):684-91.</ref> | ||
Revision as of 17:04, 30 October 2012
|
Dermatomyositis Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Dermatomyositis pathophysiology On the Web |
|
American Roentgen Ray Society Images of Dermatomyositis pathophysiology |
|
Risk calculators and risk factors for Dermatomyositis pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
On the muscle biopsy, there are two classic microscopic findings of dermatomyositis. They are:
Dermatomyositis is associated with autoantibodies, especially anti-Jo1 antibody.[1]
Mechanism
The mechanism is conjectured to be complement-mediated damage of microscopic vessels with muscle atrophy and lymphocytic inflammation secondary to tissue ischemia.[2]
Microscopic findings
Cross sections of muscle reveal muscle fascicles with small, shrunken polygonal muscle fibers on the periphery of a fascicle surrounding central muscle fibers of normal, uniform size. Aggregates of mature lymphocytes with small, dark nuclei and scant cytoplasm are seen surrounding vessels. Other inflammatory cells are distinctly uncommon. Immunohistochemistry can be used to demonstrate that both B- and T-cells are present in approximately equal numbers.[3] [4]
References
- ↑ Ghirardello, A (2006). "Clinical implications of autoantibody screening in patients with autoimmune myositis". Autoimmunity. 39 (3): 217–221. doi:10.1080/08916930600622645. PMID 16769655. Unknown parameter
|coauthors=ignored (help); Unknown parameter|month=ignored (help) - ↑ Benveniste, O (2004). "Pathogenesis of primary inflammatory myopathies". Presse Médicale. 33 (20): 1444–1450. doi:10.1016/S0755-4982(04)98952-X. PMID 15611679. Unknown parameter
|coauthors=ignored (help); Unknown parameter|month=ignored (help) - ↑ Benveniste O, Squier W, Boyer O, Hilton-Jones D, Herson S. Presse Med. 2004 Nov 20;33(20):1444-50. PMID: 15611679
- ↑ Nirmalananthan N, Holton JL, Hanna MG. Is it really myositis? A consideration of the differential diagnosis. Curr Opin Rheumatol. 2004 Nov;16(6):684-91.