Keratoconjunctivitis sicca pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
==Pathophysiology== | ==Pathophysiology== | ||
Having dry eyes for a while can lead to tiny [[abrasion]]s on the surface of the eyes. In advanced cases, the [[epithelium]] undergoes pathologic changes, namely [[squamous metaplasia]] and loss of [[goblet cell]]s. Some severe cases result in thickening of the corneal surface, corneal erosion, punctate keratopathy, [[epithelium|epithelial]] defects, [[corneal ulcer]]ation (sterile and infected), corneal [[neovascularization]], corneal scarring, corneal thinning, and even corneal perforation. | Having dry eyes for a while can lead to tiny [[abrasion]]s on the surface of the eyes.<ref name=MedlinePlus-1/> In advanced cases, the [[epithelium]] undergoes pathologic changes, namely [[squamous metaplasia]] and loss of [[goblet cell]]s. Some severe cases result in thickening of the corneal surface,<ref name=Merck-1/> corneal erosion, punctate keratopathy, [[epithelium|epithelial]] defects, [[corneal ulcer]]ation (sterile and infected), corneal [[neovascularization]], corneal scarring,<ref name=Merck-1/> corneal thinning, and even corneal perforation. | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Having dry eyes for a while can lead to tiny abrasions on the surface of the eyes.[1] In advanced cases, the epithelium undergoes pathologic changes, namely squamous metaplasia and loss of goblet cells. Some severe cases result in thickening of the corneal surface,[2] corneal erosion, punctate keratopathy, epithelial defects, corneal ulceration (sterile and infected), corneal neovascularization, corneal scarring,[2] corneal thinning, and even corneal perforation.