Lupoid hepatitis: Difference between revisions
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==Overview== | ==Overview== | ||
'''Lupoid hepatitis''' (also called Autoimmune hepatitis) is an [[auto-immune disease]] which causes liver [[cirrhosis]]. It may be associated with [[systemic lupus erythematosus]] (SLE) or other [[connective tissue disorder]]s. 60% of patients have chronic [[hepatitis]] that may mimic viral hepatitis, but without [[serology|serologic]] evidence of a [[viral infection]]. The disease usually affects women and is strongly associated with anti-[[smooth muscle]] auto-[[antibody|antibodies]]. | '''Lupoid hepatitis''' (also called Autoimmune hepatitis) is an [[auto-immune disease]] which causes liver [[cirrhosis]]. It may be associated with [[systemic lupus erythematosus]] (SLE) or other [[connective tissue disorder]]s. 60% of patients have chronic [[hepatitis]] that may mimic viral hepatitis, but without [[serology|serologic]] evidence of a [[viral infection]]. The disease usually affects women and is strongly associated with anti-[[smooth muscle]] auto-[[antibody|antibodies]]. | ||
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* Krawitt, E. L. 1996. Autoimmune hepatitis. New England Journal of Medicine. 334:897-903. | * Krawitt, E. L. 1996. Autoimmune hepatitis. New England Journal of Medicine. 334:897-903. | ||
[[Category:Hepatitis]] | [[Category:Hepatitis]] |
Latest revision as of 14:25, 2 November 2012
Lupoid hepatitis | |
Autoimmune hepatitis. Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: Autoimmune hepatitis
Overview
Lupoid hepatitis (also called Autoimmune hepatitis) is an auto-immune disease which causes liver cirrhosis. It may be associated with systemic lupus erythematosus (SLE) or other connective tissue disorders. 60% of patients have chronic hepatitis that may mimic viral hepatitis, but without serologic evidence of a viral infection. The disease usually affects women and is strongly associated with anti-smooth muscle auto-antibodies. Autoimmune hepatitis is a condition in which the patient's own immune systems attacks the liver causing inflammation and liver cell death. The condition is chronic and progressive. Although the disease is chronic, many patients with autoimmune hepatitis present acutely ill with jaundice, fever and sometimes symptoms of severe hepatic dysfunction, a picture that resembles acute hepatitis.
References
- Krawitt, E. L. 1996. Autoimmune hepatitis. New England Journal of Medicine. 334:897-903.