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(/* 2010 AASLD/ACG Alcoholic Liver Disease Guidelines : Laboratory Tests (DO NOT EDIT){{cite web |url=http://www.aasld.org/practiceguidelines/Documents/Bookmarked%20Practice%20Guidelines/AlcoholicLiverDisease1-2010.pdf |title=www.aasld.org |format=...)
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==2010 AASLD/ACG Alcoholic Liver Disease Guidelines (DO NOT EDIT)<ref name="urlwww.aasld.org">{{cite web |url=http://www.aasld.org/practiceguidelines/Documents/Bookmarked%20Practice%20Guidelines/AlcoholicLiverDisease1-2010.pdf |title=www.aasld.org |format= |work= |accessdate=2012-10-27}}</ref>==
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Revision as of 05:33, 16 November 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Pertinent laboratory findings include elevated liver enzymes, with an AST to ALT ratio of about 2 to 1. An elevated level of gamma-glutamyl transferase is an indicator of excessive alcohol consumption. Other findings include; and increase serum bilirubin, increased alkaline phosphatase, a prolonged prothrombin time, decreased serum albumin, thrombocytopenia, leukocytosis, folate deficiency, and a macrocytic anemia.

Laboratory Findings

Hemogram

Liver Function Tests

Diagnosis typically relies on laboratory tests of three liver enzymes: gamma–glutamyl transferase (GGT), aspartate aminotransferase (AST), and alanine aminotransferase (ALT). Liver disease is the most likely diagnosis if the AST level is more than twice that of ALT [1], a ratio some studies have found in more than 80 percent of alcoholic liver disease patients. An elevated level of the liver enzyme GGT is another gauge of heavy alcohol use and liver injury. Of the three enzymes, GGT is the best indicator of excessive alcohol consumption, but GGT is present in many organs and is increased by other drugs as well, so high GGT levels do not necessarily mean the patient is abusing alcohol.

2010 AASLD/ACG Alcoholic Liver Disease Guidelines (DO NOT EDIT)[2]

Laboratory Tests : Guidelines (DO NOT EDIT)[2]

Class I
1. " For patients with a history of alcohol abuse or excess and evidence of liver disease, further laboratory tests should be done to exclude other etiologies and to confirm the diagnosis. (Level of evidence: C) "

References

  1. Marsano, L.S.; Mendez, C.; Hill, D.; et al. Diagnosis and treatment of alcoholic liver disease and its complications. Alcohol Research & Health 27(3):247–256, 2003
  2. 2.0 2.1 "www.aasld.org" (PDF). Retrieved 2012-10-27.

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