Neurosyphilis pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Pathophysiology

Neurosyphilis is caused by Treponema pallidum, the bacteria that cause syphilis. It usually occurs about 10 - 20 years after a person is first infected with syphilis. Not everyone who has syphilis will develop this complication.

There are four different forms of neurosyphilis:

• Asymptomatic (most common form)
• General paresis
• Meningovascular
• Tabes dorsalis

Asymptomatic neurosyphilis occurs before symptomatic syphilis.