Kaposi's sarcoma pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
Despite its name, it is generally not considered a true [[sarcoma]], which is a tumor arising from [[mesenchyme|mesenchymal tissue]]. KS actually arises as a cancer of [[lymphatic]] [[endothelium]] and forms vascular channels that fill with blood cells, giving the tumor its characteristic bruise-like appearance. | Despite its name, it is generally not considered a true [[sarcoma]], which is a tumor arising from [[mesenchyme|mesenchymal tissue]]. KS actually arises as a cancer of [[lymphatic]] [[endothelium]] and forms vascular channels that fill with blood cells, giving the tumor its characteristic bruise-like appearance. [[Image:Kaposi's sarcoma patho.jpg|thumb|200px|left|[[Micrograph]] of a Kaposi's sarcoma showing the characteristic spindle cells, high [[vascular]]ity and [[intracellular]] [[hyaline]] globs. [[H&E stain]].]] | ||
KS lesions contain tumor [[cell (biology)|cells]] with a characteristic abnormal elongated shape, called ''spindle cells''. The tumor is highly [[Blood vessel|vascular]], containing abnormally dense and irregular blood vessels, which leak red blood cells into the surrounding tissue and give the tumor its dark color. [[Inflammation]] around the tumor may produce swelling and pain. | KS lesions contain tumor [[cell (biology)|cells]] with a characteristic abnormal elongated shape, called ''spindle cells''. The tumor is highly [[Blood vessel|vascular]], containing abnormally dense and irregular blood vessels, which leak red blood cells into the surrounding tissue and give the tumor its dark color. [[Inflammation]] around the tumor may produce swelling and pain. |
Revision as of 14:52, 29 November 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Despite its name, it is generally not considered a true sarcoma, which is a tumor arising from mesenchymal tissue. KS actually arises as a cancer of lymphatic endothelium and forms vascular channels that fill with blood cells, giving the tumor its characteristic bruise-like appearance.
KS lesions contain tumor cells with a characteristic abnormal elongated shape, called spindle cells. The tumor is highly vascular, containing abnormally dense and irregular blood vessels, which leak red blood cells into the surrounding tissue and give the tumor its dark color. Inflammation around the tumor may produce swelling and pain.