Amyotrophic lateral sclerosis classification: Difference between revisions
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* "Familial ALS" accounts for approximately 5%-10% of all ALS cases and is caused by genetic factors. Of these approximately 10% are linked to a mutation in [[Superoxide dismutase]] (SOD1), a copper/zinc dependant dismutase that is responsible for scavenging free radicals. | * "Familial ALS" accounts for approximately 5%-10% of all ALS cases and is caused by genetic factors. Of these approximately 10% are linked to a mutation in [[Superoxide dismutase]] (SOD1), a copper/zinc dependant dismutase that is responsible for scavenging free radicals. | ||
* Most of the remaining 90-95% of cases are classified as "sporadic ALS" and have no known hereditary component. | * Most of the remaining 90-95% of cases are classified as "sporadic ALS" and have no known hereditary component. | ||
* A third type, called "Guamanian ALS", represents a small cluster of cases concentrated on the Pacific island of Guam. | * A third type, called "Guamanian ALS", represents a small cluster of cases concentrated on the Pacific island of Guam. | ||
==Guamanian ALS== | |||
There was a high inicidence of this rare form of ALS from the 1940s to the 1960's, and during this thie, the rates of ALS increased by 50 to 100 times of its incidence prior to this time. The incidence of Guamanian ALS has dropped significantly since the 1960's, but during it's peak, it killed more than 10% of the native Chamorro people of Guam. | |||
===Parkinson's and Alzheimers Association=== | |||
Unique to the Guamanian form of ALS | |||
==References== | ==References== |
Revision as of 18:02, 3 December 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
ALS is classified into three general groups, familial ALS, sporadic ALS and Guamanian ALS.
Classification
- "Familial ALS" accounts for approximately 5%-10% of all ALS cases and is caused by genetic factors. Of these approximately 10% are linked to a mutation in Superoxide dismutase (SOD1), a copper/zinc dependant dismutase that is responsible for scavenging free radicals.
- Most of the remaining 90-95% of cases are classified as "sporadic ALS" and have no known hereditary component.
- A third type, called "Guamanian ALS", represents a small cluster of cases concentrated on the Pacific island of Guam.
Guamanian ALS
There was a high inicidence of this rare form of ALS from the 1940s to the 1960's, and during this thie, the rates of ALS increased by 50 to 100 times of its incidence prior to this time. The incidence of Guamanian ALS has dropped significantly since the 1960's, but during it's peak, it killed more than 10% of the native Chamorro people of Guam.
Parkinson's and Alzheimers Association
Unique to the Guamanian form of ALS