Yellow fever history and symptoms: Difference between revisions
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== | ==History and Symptoms== | ||
The virus remains silent in the body during an [[incubation period]] of three to six days. There are then two disease phases. While some infections have no symptoms the first, ''acute'' phase is normally characterized by fever, muscle pain (with prominent backache), headache, shivers, loss of appetite, and nausea or vomiting. The high fever is often paradoxically associated with a slow pulse (known as [[Faget's sign]]). After three or four days most patients improve and their symptoms disappear. | |||
Fifteen percent of patients, however, enter a ''toxic phase'' within 24 hours. Fever reappears and several body systems are affected. The patient rapidly develops [[jaundice]] and complains of abdominal pain with vomiting. Bleeding can occur from the mouth, nose, eyes, and stomach. Once this happens blood appears in the vomit and feces. [[Kidney function]] deteriorates; this can range from abnormal protein levels in the urine ([[proteinuria]]) to [[acute renal failure|complete kidney failure]] with no urine production ([[anuria]]). Half of the patients in the "toxic phase" die within fourteen days. The remainder recover without significant organ damage. | Fifteen percent of patients, however, enter a ''toxic phase'' within 24 hours. Fever reappears and several body systems are affected. The patient rapidly develops [[jaundice]] and complains of abdominal pain with vomiting. Bleeding can occur from the mouth, nose, eyes, and stomach. Once this happens blood appears in the vomit and feces. [[Kidney function]] deteriorates; this can range from abnormal protein levels in the urine ([[proteinuria]]) to [[acute renal failure|complete kidney failure]] with no urine production ([[anuria]]). Half of the patients in the "toxic phase" die within fourteen days. The remainder recover without significant organ damage. | ||
Yellow fever is difficult to recognize, especially during the early stages. It can easily be confused with [[malaria]], [[typhoid]], [[rickettsial]] diseases, [[haemorrhagic viral fever]]s (e.g. Lassa), [[arbovirus|arboviral]] infections (e.g. [[dengue fever|dengue]]), [[leptospirosis]], [[viral hepatitis]] and poisoning (e.g. [[carbon tetrachloride]]). A laboratory analysis is required to confirm a suspect case. Blood tests (serology assays) can detect yellow fever [[antibodies]] that are produced in response to the infection. Several other techniques are used to identify the virus itself in blood specimens or liver tissue collected after death. These tests require highly trained laboratory staff using specialized equipment and materials. | Yellow fever is difficult to recognize, especially during the early stages. It can easily be confused with [[malaria]], [[typhoid]], [[rickettsial]] diseases, [[haemorrhagic viral fever]]s (e.g. Lassa), [[arbovirus|arboviral]] infections (e.g. [[dengue fever|dengue]]), [[leptospirosis]], [[viral hepatitis]] and poisoning (e.g. [[carbon tetrachloride]]). A laboratory analysis is required to confirm a suspect case. Blood tests (serology assays) can detect yellow fever [[antibodies]] that are produced in response to the infection. Several other techniques are used to identify the virus itself in blood specimens or liver tissue collected after death. These tests require highly trained laboratory staff using specialized equipment and materials. | ||
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Revision as of 16:35, 7 December 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
History and Symptoms
The virus remains silent in the body during an incubation period of three to six days. There are then two disease phases. While some infections have no symptoms the first, acute phase is normally characterized by fever, muscle pain (with prominent backache), headache, shivers, loss of appetite, and nausea or vomiting. The high fever is often paradoxically associated with a slow pulse (known as Faget's sign). After three or four days most patients improve and their symptoms disappear.
Fifteen percent of patients, however, enter a toxic phase within 24 hours. Fever reappears and several body systems are affected. The patient rapidly develops jaundice and complains of abdominal pain with vomiting. Bleeding can occur from the mouth, nose, eyes, and stomach. Once this happens blood appears in the vomit and feces. Kidney function deteriorates; this can range from abnormal protein levels in the urine (proteinuria) to complete kidney failure with no urine production (anuria). Half of the patients in the "toxic phase" die within fourteen days. The remainder recover without significant organ damage. Yellow fever is difficult to recognize, especially during the early stages. It can easily be confused with malaria, typhoid, rickettsial diseases, haemorrhagic viral fevers (e.g. Lassa), arboviral infections (e.g. dengue), leptospirosis, viral hepatitis and poisoning (e.g. carbon tetrachloride). A laboratory analysis is required to confirm a suspect case. Blood tests (serology assays) can detect yellow fever antibodies that are produced in response to the infection. Several other techniques are used to identify the virus itself in blood specimens or liver tissue collected after death. These tests require highly trained laboratory staff using specialized equipment and materials.