Lassa fever primary prevention: Difference between revisions
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==Primary Prevention== | ==Primary Prevention== | ||
Primary transmission of the Lassa virus from its host to humans can be prevented by avoiding contact with Mastomys rodents, especially in the geographic regions where outbreaks occur. Putting food away in rodent-proof containers and keeping the home clean help to discourage rodents from entering homes. Using these rodents as a food source is not recommended. Trapping in and around homes can help reduce rodent populations. | |||
Control of the ''Mastomys'' rodent population is impractical, so measures are limited to keeping rodents out of homes and food supplies, as well as maintaining effective personal hygiene. Gloves, masks, laboratory coats, and goggles are advised while in contact with an infected person. | Control of the ''Mastomys'' rodent population is impractical, so measures are limited to keeping rodents out of homes and food supplies, as well as maintaining effective personal hygiene. Gloves, masks, laboratory coats, and goggles are advised while in contact with an infected person. | ||
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Researchers at the [[USAMRIID]] facility, where military biologists study infectious diseases, have a promising vaccine candidate. They have developed a [[Virus#Replication|replication]]-competent vaccine against Lassa virus based on recombinant vesicular [[stomatitis]] [[Vesicular stomatitis virus|virus]] vectors expressing the Lassa virus glycoprotein. After a single [[Intramuscular|intramuscular injection]], test primates have survived lethal challenge, while showing no clinical symptoms.<ref>{{cite journal |author=Geisbert TW, Jones S, Fritz EA, ''et al'' |title=Development of a new vaccine for the prevention of Lassa fever |journal=PLoS Med. |volume=2 |issue=6 |pages=e183 |year=2005 |pmid=15971954 |doi=10.1371/journal.pmed.0020183}}</ref> | Researchers at the [[USAMRIID]] facility, where military biologists study infectious diseases, have a promising vaccine candidate. They have developed a [[Virus#Replication|replication]]-competent vaccine against Lassa virus based on recombinant vesicular [[stomatitis]] [[Vesicular stomatitis virus|virus]] vectors expressing the Lassa virus glycoprotein. After a single [[Intramuscular|intramuscular injection]], test primates have survived lethal challenge, while showing no clinical symptoms.<ref>{{cite journal |author=Geisbert TW, Jones S, Fritz EA, ''et al'' |title=Development of a new vaccine for the prevention of Lassa fever |journal=PLoS Med. |volume=2 |issue=6 |pages=e183 |year=2005 |pmid=15971954 |doi=10.1371/journal.pmed.0020183}}</ref> | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 19:44, 20 December 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Primary Prevention
Primary transmission of the Lassa virus from its host to humans can be prevented by avoiding contact with Mastomys rodents, especially in the geographic regions where outbreaks occur. Putting food away in rodent-proof containers and keeping the home clean help to discourage rodents from entering homes. Using these rodents as a food source is not recommended. Trapping in and around homes can help reduce rodent populations.
Control of the Mastomys rodent population is impractical, so measures are limited to keeping rodents out of homes and food supplies, as well as maintaining effective personal hygiene. Gloves, masks, laboratory coats, and goggles are advised while in contact with an infected person.
No vaccine against Lassa fever is currently available, though development is underway. The Mozambique virus closely resembles Lassa fever, while lacking its deadly effects. This virus is being considered for possible use as a vaccine.
Researchers at the USAMRIID facility, where military biologists study infectious diseases, have a promising vaccine candidate. They have developed a replication-competent vaccine against Lassa virus based on recombinant vesicular stomatitis virus vectors expressing the Lassa virus glycoprotein. After a single intramuscular injection, test primates have survived lethal challenge, while showing no clinical symptoms.[1]
References
- ↑ Geisbert TW, Jones S, Fritz EA; et al. (2005). "Development of a new vaccine for the prevention of Lassa fever". PLoS Med. 2 (6): e183. doi:10.1371/journal.pmed.0020183. PMID 15971954.