Pott's disease pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
Pott's disease occurs usually due to | Pott's disease occurs usually due to hematogenous spread of [[infection]] from an extraspinal source. Pott's disease usually involves more than one [[vertebra]] and manifests as a combination of [[osteomyelitis]] and [[arthritis]]. First anterior aspect of the vertebral body adjacent to the subchondral plate is affected. Then [[tuberculosis]] may spread into adjacent intervertebral disks. Intervertebral disk disease occurs due to spread of infection from the vertebral body in adults, whereas the disk can be the primary site of infection in children because it is vascularized. This is followed by progressive bone destruction, which leads to vertebral collapse and [[kyphosis]]. Tuberculous abscesses, [[granuloma]]s, and direct invasion of dura may cause narrowing of [[spinal canal]], which leads to [[cord compression]] and neurologic deficits. [[Kyphosis]] occurs more likely due to lesions in the [[thoracic spine]] than the [[lumbar spine]]. Collapse in the anterior spine is responsible for [[kyphosis]]. If the infection extends to adjacent [[ligament]]s and soft tissues, cold abscess may develop. In the lumbar region, [[abscess]]es may descend down the sheath of the psoas muscle to the femoral trigone and eventually invade the skin. | ||
==References== | ==References== | ||
Revision as of 20:19, 21 December 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hardik Patel, M.D.
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Overview
Pott's disease occurs usually due to hematogenous spread of tuberculous infection from an extraspinal source. Pott's disease usually involves more than one vertebra and manifests as a combination of osteomyelitis and arthritis.
Pathophysiology
Pott's disease occurs usually due to hematogenous spread of infection from an extraspinal source. Pott's disease usually involves more than one vertebra and manifests as a combination of osteomyelitis and arthritis. First anterior aspect of the vertebral body adjacent to the subchondral plate is affected. Then tuberculosis may spread into adjacent intervertebral disks. Intervertebral disk disease occurs due to spread of infection from the vertebral body in adults, whereas the disk can be the primary site of infection in children because it is vascularized. This is followed by progressive bone destruction, which leads to vertebral collapse and kyphosis. Tuberculous abscesses, granulomas, and direct invasion of dura may cause narrowing of spinal canal, which leads to cord compression and neurologic deficits. Kyphosis occurs more likely due to lesions in the thoracic spine than the lumbar spine. Collapse in the anterior spine is responsible for kyphosis. If the infection extends to adjacent ligaments and soft tissues, cold abscess may develop. In the lumbar region, abscesses may descend down the sheath of the psoas muscle to the femoral trigone and eventually invade the skin.