Kikuchi disease pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
Some studies have suggested a genetic predisposition to the proposed autoimmune response. Several infectious candidates have been associated with Kikuchi's disease<ref name="pmid18462833">{{cite journal| author=Atwater AR, Longley BJ, Aughenbaugh WD| title=Kikuchi's disease: case report and systematic review of cutaneous and histopathologic presentations. | journal=J Am Acad Dermatol | year= 2008 | volume= 59 | issue= 1 | pages= 130-6 | pmid=18462833 | doi=10.1016/j.jaad.2008.03.012 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18462833 }} </ref>. | Some studies have suggested a [[genetic predisposition]] to the proposed [[autoimmune]] response. Several [[infectious]] candidates have been associated with Kikuchi's disease<ref name="pmid18462833">{{cite journal| author=Atwater AR, Longley BJ, Aughenbaugh WD| title=Kikuchi's disease: case report and systematic review of cutaneous and histopathologic presentations. | journal=J Am Acad Dermatol | year= 2008 | volume= 59 | issue= 1 | pages= 130-6 | pmid=18462833 | doi=10.1016/j.jaad.2008.03.012 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18462833 }} </ref>. | ||
There are many postulates about the etiology of KFD. A microbial/viral or autoimmune cause has been suggested. Mycobacterium szulgai, Yesinia and Toxoplasma have been implicated. More recently there has been growing evidence of the role of Epstein-Barr virus, as well as other viruses (HHV6, HHV8, Parvovirus B19, HIV- and HTLV-1) in the pathogenesis of KFD. <ref name="PMID22762705">{{cite journal |author=Rammohan A, Cherukuri SD, Manimaran AB, Manohar RR, Naidu RM|title=Kikuchi-Fujimoto Disease: A Sheep in Wolf's Clothing |journal=J Otolaryngol Head Neck Surg|volume=41 |issue=3 |pages=222–226 |year=2012 |month=June|pmid=22762705|}}</ref> But serologic tests including antibodies to a host of viruses have consistently proven noncontributory and no viral particles have been identified ultrastructurally. | There are many postulates about the [[etiology]] of KFD. A [[microbial]]/ [[viral]] or autoimmune cause has been suggested. [[Mycobacterium]] szulgai, Yesinia and Toxoplasma have been implicated. More recently there has been growing evidence of the role of Epstein-Barr virus, as well as other viruses (HHV6, HHV8, Parvovirus B19, HIV- and HTLV-1) in the pathogenesis of KFD. <ref name="PMID22762705">{{cite journal |author=Rammohan A, Cherukuri SD, Manimaran AB, Manohar RR, Naidu RM|title=Kikuchi-Fujimoto Disease: A Sheep in Wolf's Clothing |journal=J Otolaryngol Head Neck Surg|volume=41 |issue=3 |pages=222–226 |year=2012 |month=June|pmid=22762705|}}</ref> But serologic tests including antibodies to a host of viruses have consistently proven noncontributory and no viral particles have been identified ultrastructurally. | ||
It is now proposed that KFD is a nonspecific hyperimmune reaction to a variety of infectious, chemical, physical and neoplastic agents. In addition to SLE, other autoimmune conditions and manifestations such as antiphospholipid syndrome, polymyositis, systemic juvenile idiopathic arthritis, bilateral uveitis, arthritis and cutaneous necrotizing vasculitis have been linked to KFD. It is possible that KFD may represent an exuberant T-cell mediated immune response in a genetically susceptible individual to a variety of non-specific stimuli. <ref name="PMID22762705">{{cite journal |author=Rammohan A, Cherukuri SD, Manimaran AB, Manohar RR, Naidu RM|title=Kikuchi-Fujimoto Disease: A Sheep in Wolf's Clothing |journal=J Otolaryngol Head Neck Surg|volume=41 |issue=3 |pages=222–226 |year=2012 |month=June|pmid=22762705|}}</ref> | It is now proposed that KFD is a nonspecific hyperimmune reaction to a variety of infectious, chemical, physical and neoplastic agents. In addition to SLE, other autoimmune conditions and manifestations such as antiphospholipid syndrome, polymyositis, systemic juvenile idiopathic arthritis, bilateral uveitis, arthritis and cutaneous necrotizing vasculitis have been linked to KFD. It is possible that KFD may represent an exuberant T-cell mediated immune response in a genetically susceptible individual to a variety of non-specific stimuli. <ref name="PMID22762705">{{cite journal |author=Rammohan A, Cherukuri SD, Manimaran AB, Manohar RR, Naidu RM|title=Kikuchi-Fujimoto Disease: A Sheep in Wolf's Clothing |journal=J Otolaryngol Head Neck Surg|volume=41 |issue=3 |pages=222–226 |year=2012 |month=June|pmid=22762705|}}</ref> | ||
===Associated Conditions=== | ===Associated Conditions=== | ||
Revision as of 17:26, 26 December 2012
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Pathophysiology
Some studies have suggested a genetic predisposition to the proposed autoimmune response. Several infectious candidates have been associated with Kikuchi's disease[1].
There are many postulates about the etiology of KFD. A microbial/ viral or autoimmune cause has been suggested. Mycobacterium szulgai, Yesinia and Toxoplasma have been implicated. More recently there has been growing evidence of the role of Epstein-Barr virus, as well as other viruses (HHV6, HHV8, Parvovirus B19, HIV- and HTLV-1) in the pathogenesis of KFD. [2] But serologic tests including antibodies to a host of viruses have consistently proven noncontributory and no viral particles have been identified ultrastructurally. It is now proposed that KFD is a nonspecific hyperimmune reaction to a variety of infectious, chemical, physical and neoplastic agents. In addition to SLE, other autoimmune conditions and manifestations such as antiphospholipid syndrome, polymyositis, systemic juvenile idiopathic arthritis, bilateral uveitis, arthritis and cutaneous necrotizing vasculitis have been linked to KFD. It is possible that KFD may represent an exuberant T-cell mediated immune response in a genetically susceptible individual to a variety of non-specific stimuli. [2]
Associated Conditions
Kikuchi's disease has been reported to be associated with infections such as:
References
- ↑ Atwater AR, Longley BJ, Aughenbaugh WD (2008). "Kikuchi's disease: case report and systematic review of cutaneous and histopathologic presentations". J Am Acad Dermatol. 59 (1): 130–6. doi:10.1016/j.jaad.2008.03.012. PMID 18462833.
- ↑ 2.0 2.1 Rammohan A, Cherukuri SD, Manimaran AB, Manohar RR, Naidu RM (2012). "Kikuchi-Fujimoto Disease: A Sheep in Wolf's Clothing". J Otolaryngol Head Neck Surg. 41 (3): 222–226. PMID 22762705. Unknown parameter
|month=ignored (help)