MICU intern's survival guide vasopressors: Difference between revisions
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====Doses==== | ====Doses==== | ||
* 1-30 mcg/min. | * 1-30 mcg/min. | ||
===Dopamine=== | ===Dopamine=== | ||
====Mechanism of action==== | ====Mechanism of action==== | ||
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* '''Doses''' | * '''Doses''' | ||
* 1-20 mcg/min. | * 1-20 mcg/min. | ||
===Dobutamine=== | |||
===Vasopressin=== | |||
===Phenylephrine=== | ===Phenylephrine=== | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
{{WH}} {{WS}} | {{WH}} {{WS}} | ||
Revision as of 14:47, 28 December 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Norepinephrine
Mechanism of action
Acts on both alpha1 (vasoconstriction of blood vessels) and beta1 receptors (increases cardiac output).
Indications
- Septic shock
- Cardiogenic shock - Recent studies have shown that norepinephrine may be better than dopamine in cardiogenic shock due to a decreased risk of tachyarrhythmias.
- In cases where the type of shock is unclear, norepinephrine can be tried as a first line agent.
Doses
- 1-30 mcg/min.
Dopamine
Mechanism of action
- Acts on alpha1 (vasoconstriction of blood vessels), beta1 (increases cardiac output) and dopamine receptors (scattered throughout the body).
- Its action is dose dependent. At low doses it predominantly acts on cardiac receptors (1-10 mcg/min) with less vasoconstriction activities. At higher doses it has both vasoconstriction and cardiac activities.
Indications
- Cardiogenic shock
- Septic shock - second line treatment for septic shock
Side-effects
- Arrhythmogenic. Avoid in patients prone to arrhythmias.
- Doses
- 1-20 mcg/min.