Tetralogy of fallot causes: Difference between revisions
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{{CMG}}; '''Associate Editors-In-Chief:''' [[Priyamvada Singh| Priyamvada Singh, M.B.B.S.]] [mailto:psingh13579@gmail.com], [[User:KeriShafer|Keri Shafer, M.D.]] [mailto:kshafer@bidmc.harvard.edu]; '''Assistant Editor-In-Chief:''' [[Kristin Feeney|Kristin Feeney, B.S.]] [mailto:kfeeney@elon.edu] | {{CMG}}; '''Associate Editors-In-Chief:''' [[Priyamvada Singh| Priyamvada Singh, M.B.B.S.]] [mailto:psingh13579@gmail.com], [[User:KeriShafer|Keri Shafer, M.D.]] [mailto:kshafer@bidmc.harvard.edu]; '''Assistant Editor-In-Chief:''' [[Kristin Feeney|Kristin Feeney, B.S.]] [mailto:kfeeney@elon.edu] | ||
==Overview== | ==Overview== | ||
Both environmental and genetic factors appear to be involved in the development of | Both environmental and [[genetic]] factors appear to be involved in the development of tetralogy of Fallot. | ||
==Causes== | ==Causes== | ||
===Potential Environmental Causes or Influences=== | ===Potential Environmental Causes or Influences=== | ||
Revision as of 14:01, 25 January 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Priyamvada Singh, M.B.B.S. [2], Keri Shafer, M.D. [3]; Assistant Editor-In-Chief: Kristin Feeney, B.S. [4]
Overview
Both environmental and genetic factors appear to be involved in the development of tetralogy of Fallot.
Causes
Potential Environmental Causes or Influences
Factors that increase the risk for this condition during pregnancy include:
- Alcoholism in the mother
- Diabetes
- Pregnancy after the age of 40
- Poor nutrition during pregnancy
- Rubella or other viral illnesses during pregnancy
- Phenylketonuria (PKU) in the mother
- Fetal hydantoin syndrome
- Fetal carbamazepine syndrome
Genetic Causes
- There is a high incidence of chromosomal disorders in children with Tetralogy of Fallot
- Tetralogy of Fallot is associated with:
- Down syndrome
- DiGeorge syndrome (a 22q11.2 deletion, a condition associated with heart defects, hypocalcemia, and immune deficiency)
- A gene polymorphism at the methylene tetrahydrofolate reductase (MTHFR) region has been associated with tetralogy of Fallot [1][2]
References
- ↑ Marinho C, Alho I, Guerra A, Rego C, Areias J, Bicho M. The methylenetetrahydrofolate reductase gene variant (C677T) as a susceptibility gene for tetralogy of Fallot. Rev Port Cardiol. Jul-Aug 2009;28(7-8):809-12.
- ↑ Lee CN, Su YN, Cheng WF, Lin MT, Wang JK, Wu MH, et al. Association of the C677T methylenetetrahydrofolate reductase mutation with congenital heart diseases. Acta Obstet Gynecol Scand. Dec 2005;84(12):1134-40.
de:Fallot-Tetralogie it:Tetralogia di Fallot nl:Tetralogie van Fallot nn:Fallots tetrade uk:Тетрада Фалло