Glaucoma pathophysiology: Difference between revisions
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There is increasing evidence of [[ocular]] blood flow to be involved in the [[pathogenesis]] of glaucoma. Current data indicate that fluctuations in blood flow are more harmful in glaucomatous [[optic neuropathy]] than steady reductions. Unstable [[blood pressure]] and dips are linked to [[optic nerve]] head damage and correlate with [[visual field]] deterioration.[[Image:Human eye cross-sectional view grayscale.png|thumb|220px|left|Human eye cross-sectional view. Courtesy [[National Institutes of Health|NIH]] [[National Eye Institute]]]] | There is increasing evidence of [[ocular]] blood flow to be involved in the [[pathogenesis]] of glaucoma. Current data indicate that fluctuations in blood flow are more harmful in glaucomatous [[optic neuropathy]] than steady reductions. Unstable [[blood pressure]] and dips are linked to [[optic nerve]] head damage and correlate with [[visual field]] deterioration.[[Image:Human eye cross-sectional view grayscale.png|thumb|220px|left|Human eye cross-sectional view. Courtesy [[National Institutes of Health|NIH]] [[National Eye Institute]]]] | ||
A number of studies also suggest that there is a correlation, not necessarily causal, between glaucoma and systemic [[hypertension]] (i.e. high [[blood pressure]]). In normal tension glaucoma, [[nocturnal]] [[hypotension]] may play a significant role. On the other hand there is no clear evidence that [[vitamin]] deficiencies cause glaucoma in humans, nor that oral vitamin supplementation is useful in glaucoma treatment<ref name="pmid11525790">{{cite journal| author=Rhee DJ, Katz LJ, Spaeth GL, Myers JS| title=Complementary and alternative medicine for glaucoma. | journal=Surv Ophthalmol | year= 2001 | volume= 46 | issue= 1 | pages= 43-55 | pmid=11525790 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11525790 }} </ref>. | A number of studies also suggest that there is a correlation, not necessarily causal, between glaucoma and systemic [[hypertension]] (i.e. high [[blood pressure]]). In normal tension glaucoma, [[nocturnal]] [[hypotension]] may play a significant role. On the other hand there is no clear evidence that [[vitamin]] deficiencies cause glaucoma in humans, nor that oral [[vitamin]] supplementation is useful in glaucoma treatment<ref name="pmid11525790">{{cite journal| author=Rhee DJ, Katz LJ, Spaeth GL, Myers JS| title=Complementary and alternative medicine for glaucoma. | journal=Surv Ophthalmol | year= 2001 | volume= 46 | issue= 1 | pages= 43-55 | pmid=11525790 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11525790 }} </ref>. | ||
==References== | ==References== | ||
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Pathophysiology
There is increasing evidence of ocular blood flow to be involved in the pathogenesis of glaucoma. Current data indicate that fluctuations in blood flow are more harmful in glaucomatous optic neuropathy than steady reductions. Unstable blood pressure and dips are linked to optic nerve head damage and correlate with visual field deterioration.
A number of studies also suggest that there is a correlation, not necessarily causal, between glaucoma and systemic hypertension (i.e. high blood pressure). In normal tension glaucoma, nocturnal hypotension may play a significant role. On the other hand there is no clear evidence that vitamin deficiencies cause glaucoma in humans, nor that oral vitamin supplementation is useful in glaucoma treatment[1].
References
- ↑ Rhee DJ, Katz LJ, Spaeth GL, Myers JS (2001). "Complementary and alternative medicine for glaucoma". Surv Ophthalmol. 46 (1): 43–55. PMID 11525790.