Anaphylaxis pathophysiology: Difference between revisions
No edit summary |
No edit summary |
||
| Line 2: | Line 2: | ||
{{Anaphylaxis}} | {{Anaphylaxis}} | ||
{{CMG}} | |||
==Pathophysiology== | |||
Anaphylactic shock, the most severe type of anaphylaxis, occurs when an allergic response triggers a quick release from [[mast cell]]s of large quantities of [[immunology|immunological]] mediators ([[histamine]]s, [[prostaglandin]]s, [[leukotriene]]s) leading to systemic [[vasodilation]] (associated with a sudden drop in blood pressure) and [[edema]] of [[bronchial]] [[mucosa]] (resulting in [[bronchoconstriction]] and difficulty breathing). Anaphylactic shock can lead to death in a matter of minutes if left untreated. | |||
Researchers typically distinguish between true anaphylaxis and pseudo-anaphylaxis. The symptoms, treatment, and risk of death are identical, but "true" anaphylaxis is always caused directly by [[degranulation]] of [[mast cell]]s or basophils that is mediated by [[immunoglobulin]] E (IgE), and pseudo-anaphylaxis occurs due to all other causes. The distinction is only important for researchers who are studying mechanisms of allergic reactions. Due to the word "pseudo", it may frustrate patients who feel they are being told that a life-threatening allergic reaction isn't "real". | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Needs | [[Category:Needs overview]] | ||
[[Category:Emergency medicine]] | [[Category:Emergency medicine]] | ||
[[Category:Cardiology]] | [[Category:Cardiology]] | ||
Revision as of 21:07, 5 February 2013
|
Anaphylaxis Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Anaphylaxis pathophysiology On the Web |
|
American Roentgen Ray Society Images of Anaphylaxis pathophysiology |
|
Risk calculators and risk factors for Anaphylaxis pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Pathophysiology
Anaphylactic shock, the most severe type of anaphylaxis, occurs when an allergic response triggers a quick release from mast cells of large quantities of immunological mediators (histamines, prostaglandins, leukotrienes) leading to systemic vasodilation (associated with a sudden drop in blood pressure) and edema of bronchial mucosa (resulting in bronchoconstriction and difficulty breathing). Anaphylactic shock can lead to death in a matter of minutes if left untreated.
Researchers typically distinguish between true anaphylaxis and pseudo-anaphylaxis. The symptoms, treatment, and risk of death are identical, but "true" anaphylaxis is always caused directly by degranulation of mast cells or basophils that is mediated by immunoglobulin E (IgE), and pseudo-anaphylaxis occurs due to all other causes. The distinction is only important for researchers who are studying mechanisms of allergic reactions. Due to the word "pseudo", it may frustrate patients who feel they are being told that a life-threatening allergic reaction isn't "real".