Starvation pathophysiology: Difference between revisions

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==Pathophysiology==
==Overview==
When food intake ceases, the body enters the [[starvation response]]{{Citation needed|date=October 2011}}. Initially, the body's [[glycogen]] stores are used up in about 24 hours.{{Citation needed|date=April 2010}} The level of [[insulin]] in circulation is low and the level of [[glucagon]] is very high. The main means of energy production is [[lipolysis]]. [[Gluconeogenesis]] converts [[glycerol]] into glucose and the [[Cori cycle]] converts lactate into usable glucose.  Two systems of energy enter the gluconeogenesis: [[proteolysis]] provides [[alanine]] and [[lactic acid|lactate]] produced from [[pyruvate]], while acetyl CoA produces dissolved nutrients ([[Ketone bodies]]), which can be detected in [[urine]] and are used by the brain as a source of energy.
When food intake ceases, the body enters the [[starvation response]]{{Citation needed|date=October 2011}}. Initially, the body's [[glycogen]] stores are used up in about 24 hours.{{Citation needed|date=April 2010}} The level of [[insulin]] in circulation is low and the level of [[glucagon]] is very high. The main means of energy production is [[lipolysis]]. [[Gluconeogenesis]] converts [[glycerol]] into glucose and the [[Cori cycle]] converts lactate into usable glucose.  Two systems of energy enter the gluconeogenesis: [[proteolysis]] provides [[alanine]] and [[lactic acid|lactate]] produced from [[pyruvate]], while acetyl CoA produces dissolved nutrients ([[Ketone bodies]]), which can be detected in [[urine]] and are used by the brain as a source of energy.
In terms of insulin resistance, starvation conditions make more glucose available to the brain.
In terms of insulin resistance, starvation conditions make more glucose available to the brain.
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Revision as of 18:08, 8 February 2013

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

When food intake ceases, the body enters the starvation response[citation needed]. Initially, the body's glycogen stores are used up in about 24 hours.[citation needed] The level of insulin in circulation is low and the level of glucagon is very high. The main means of energy production is lipolysis. Gluconeogenesis converts glycerol into glucose and the Cori cycle converts lactate into usable glucose. Two systems of energy enter the gluconeogenesis: proteolysis provides alanine and lactate produced from pyruvate, while acetyl CoA produces dissolved nutrients (Ketone bodies), which can be detected in urine and are used by the brain as a source of energy. In terms of insulin resistance, starvation conditions make more glucose available to the brain.

References


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