Alstrom syndrome natural history, complications and prognosis

Alstrom syndrome Microchapters
Home
Patient Information
Overview
Historical Perspective
Pathophysiology
Differentiating Alstrom syndrome from other Diseases
Epidemiology and Demographics
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Criteria
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Chest X Ray
CT
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Tertiary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Alstrom syndrome natural history, complications and prognosis On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
slides
Images
American Roentgen Ray Society Images of Alstrom syndrome natural history, complications and prognosis All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Alstrom syndrome natural history, complications and prognosis
CDC on Alstrom syndrome natural history, complications and prognosis
Alstrom syndrome natural history, complications and prognosis in the news
Blogs on Alstrom syndrome natural history, complications and prognosis
Directions to Hospitals Treating Alstrom syndrome
Risk calculators and risk factors for Alstrom syndrome natural history, complications and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]; Raviteja Guddeti, M.B.B.S. [3]

Please help WikiDoc by adding more content here. It's easy! Click here to learn about editing.

Natural History

A wide range of clinical variability is observed among individuals with Alström syndrome, including among siblings. The first clinical presentation of Alström syndrome is usually nystagmus caused by cone-rod dystrophy and resulting in childhood blindness. Disease characteristics that are later in onset include truncal obesity that manifests during the first year of life, progressive sensorineural hearing loss, infantile-onset dilated cardiomyopathy or later-onset restrictive cardiomyopathy, insulin-resistant type 2 diabetes mellitus, and hepatic, pulmonary, and renal dysfunction.

Complications

• Blindness
• Hearing loss
• Congestive heart failure
• Cirrhosis
• Pancreatitis
• ESRD
• Hypothyroidism
• Pulmonary fibrosis
• Portal hypertension
• Type 2 diabetes mellitus
• Stunted growth