Hurler syndrome history and symptoms: Difference between revisions
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== | ==Overview== | ||
Affected children may be quite large at [[childbirth|birth]] and appear normal but may have inguinal (in the groin) or umbilical (where the [[umbilical cord]] passes through the [[abdomen]]) hernias. Growth in height may be initially faster than normal, then begins to slow before the end of the first year and often ends around age 3. Many children develop a short body trunk and a maximum stature of less than 4 feet. Distinct facial features (including flat face, depressed nasal bridge, and bulging forehead) become more evident in the second year. By age 2, the ribs have widened and are oar-shaped. The [[liver]], [[spleen]] and [[heart]] are often enlarged. Children may experience noisy breathing and recurring upper respiratory tract and [[ear]] [[infection]]s. Feeding may be difficult for some children, and many experience periodic bowel problems. Children with Hurler syndrome often die before age 10 from obstructive airway disease, respiratory infections, or cardiac complications. | Affected children may be quite large at [[childbirth|birth]] and appear normal but may have inguinal (in the groin) or umbilical (where the [[umbilical cord]] passes through the [[abdomen]]) hernias. Growth in height may be initially faster than normal, then begins to slow before the end of the first year and often ends around age 3. Many children develop a short body trunk and a maximum stature of less than 4 feet. Distinct facial features (including flat face, depressed nasal bridge, and bulging forehead) become more evident in the second year. By age 2, the ribs have widened and are oar-shaped. The [[liver]], [[spleen]] and [[heart]] are often enlarged. Children may experience noisy breathing and recurring upper respiratory tract and [[ear]] [[infection]]s. Feeding may be difficult for some children, and many experience periodic bowel problems. Children with Hurler syndrome often die before age 10 from obstructive airway disease, respiratory infections, or cardiac complications. | ||
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{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Needs content]] | [[Category:Needs content]] | ||
[[Category:Gastroenterology]] | |||
[[Category:Genetic disorders]] | |||
[[Category:Hepatology]] | |||
[[Category:Syndromes]] | |||
[[Category:Mature chapter]] | |||
[[Category:Metabolic disorders]] | |||
[[Category:Lysosomal storage diseases]] | |||
[[Category:Cardiology]] | |||
[[Category:Psychiatry]] | |||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category: | [[Category:Inborn errors of metabolism]] | ||
Revision as of 23:51, 25 February 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Affected children may be quite large at birth and appear normal but may have inguinal (in the groin) or umbilical (where the umbilical cord passes through the abdomen) hernias. Growth in height may be initially faster than normal, then begins to slow before the end of the first year and often ends around age 3. Many children develop a short body trunk and a maximum stature of less than 4 feet. Distinct facial features (including flat face, depressed nasal bridge, and bulging forehead) become more evident in the second year. By age 2, the ribs have widened and are oar-shaped. The liver, spleen and heart are often enlarged. Children may experience noisy breathing and recurring upper respiratory tract and ear infections. Feeding may be difficult for some children, and many experience periodic bowel problems. Children with Hurler syndrome often die before age 10 from obstructive airway disease, respiratory infections, or cardiac complications.
There is some clinical similarity with Hunter syndrome.