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Hepatic encephalopathy leads to changed cognitive function. This can range from subtle deficits in higher mental functions (in mild cases) to [[obtundation]] and coma (in severe cases). Left untreated, severe hepatic encephalopathy can cause death. | Hepatic encephalopathy leads to changed cognitive function. This can range from subtle deficits in higher mental functions (in mild cases) to [[obtundation]] and coma (in severe cases). Left untreated, severe hepatic encephalopathy can cause death. | ||
==Natural History== | ==Natural History== | ||
Hepatic encephalopathy may occur as an acute, potentially reversible disorder | Hepatic encephalopathy may occur as an acute, potentially reversible disorder or it may occur as a chronic, progressive disorder that is associated with chronic liver disease. | ||
==Complications== | ==Complications== | ||
*Brain herniation | *[[Brain]] [[herniation]] | ||
*Brain swelling | *Brain swelling | ||
*Increased risk of: | *Increased risk of: | ||
**Cardiovascular collapse | **[[Cardiovascular collapse]] | ||
**Kidney failure | **[[Kidney failure]] | ||
**Respiratory failure | **[[Respiratory failure]] | ||
**Sepsis | **[[Sepsis]] | ||
*Permanent nervous system damage | *Permanent nervous system damage to movement, sensation, or mental state | ||
*Progressive, irreversible coma | *Progressive, irreversible [[coma]] | ||
*Side effects of medications | *Side effects of medications | ||
==Prognosis== | ==Prognosis== |
Revision as of 17:51, 7 March 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Hepatic encephalopathy leads to changed cognitive function. This can range from subtle deficits in higher mental functions (in mild cases) to obtundation and coma (in severe cases). Left untreated, severe hepatic encephalopathy can cause death.
Natural History
Hepatic encephalopathy may occur as an acute, potentially reversible disorder or it may occur as a chronic, progressive disorder that is associated with chronic liver disease.
Complications
- Brain herniation
- Brain swelling
- Increased risk of:
- Permanent nervous system damage to movement, sensation, or mental state
- Progressive, irreversible coma
- Side effects of medications
Prognosis
Acute hepatic encephalopathy may be treatable. Chronic forms of the disorder often keep getting worse or continue to come back. Both forms may result in irreversible coma and death. Approximately 80% (8 out of 10 patients) die if they go into a coma. Recovery and the risk of the condition returning vary from patient to patient.