Diaper rash pathophysiology: Difference between revisions
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{{CMG}} {{AE}} {{VVS}} | {{CMG}} {{AE}} {{VVS}} | ||
==Pathophysiology== | ==Pathophysiology== | ||
Irritant diaper dermatitis develops when skin is exposed to prolonged wetness, increased skin [[pH]] caused by [[urine]] and [[feces]], and resulting breakdown of the [[stratum corneum]], or outermost layer of the skin. In adults, the stratum corneum is composed of 25 to 30 layers of flattened dead [[keratinocytes]], which are continuously shed and replaced from below. These dead cells are interlaid with [[lipids]] secreted by the [[stratum granulosum]] just underneath, which help to make this layer of the skin a waterproof barrier. The stratum corneum's function is to reduce water loss, repel water, protect deeper layers of the skin from injury and to repel [[Microbe|microbial]] invasion of the skin (Tortora and Grabowski, 2003). In infants, this layer of the skin is much thinner and more easily disrupted. | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 13:26, 11 March 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Vishnu Vardhan Serla M.B.B.S. [2]
Pathophysiology
Irritant diaper dermatitis develops when skin is exposed to prolonged wetness, increased skin pH caused by urine and feces, and resulting breakdown of the stratum corneum, or outermost layer of the skin. In adults, the stratum corneum is composed of 25 to 30 layers of flattened dead keratinocytes, which are continuously shed and replaced from below. These dead cells are interlaid with lipids secreted by the stratum granulosum just underneath, which help to make this layer of the skin a waterproof barrier. The stratum corneum's function is to reduce water loss, repel water, protect deeper layers of the skin from injury and to repel microbial invasion of the skin (Tortora and Grabowski, 2003). In infants, this layer of the skin is much thinner and more easily disrupted.