Rheumatoid arthritis future or investigational therapies: Difference between revisions
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==Future or Investigational Therapies== | |||
==Future | |||
===Pain relief=== | ===Pain relief=== | ||
Recent research indicates that [[cytokines]], a group of chemicals that are produced by various cells in the body, may be responsible for generating the response of chronic [[Pain and nociception|pain]] associated with Rheumatoid Arthritis. Medications that affect the release of cytokines or block the action of cytokines may reduce the response of chronic pain. Various anti-cytokine medications are now being used to treat painful disease states such as Rheumatoid Arthritis, and [[Crohn's Disease]]. In addition, research using the anti-cytokine medication, [[Thalidomide]], is being evaluated for its effect in treating chronic pain associated with [[Arachnoiditis]]. Food (vegetables) with higher water content should be avoided. | Recent research indicates that [[cytokines]], a group of chemicals that are produced by various cells in the body, may be responsible for generating the response of chronic [[Pain and nociception|pain]] associated with Rheumatoid Arthritis. Medications that affect the release of cytokines or block the action of cytokines may reduce the response of chronic pain. Various anti-cytokine medications are now being used to treat painful disease states such as Rheumatoid Arthritis, and [[Crohn's Disease]]. In addition, research using the anti-cytokine medication, [[Thalidomide]], is being evaluated for its effect in treating chronic pain associated with [[Arachnoiditis]]. Food (vegetables) with higher water content should be avoided. | ||
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==References== | ==References== | ||
{{ | {{Reflist|2}} | ||
[[Category:Aging-associated diseases]] | [[Category:Aging-associated diseases]] | ||
[[Category:Arthritis]] | [[Category:Arthritis]] | ||
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[[Category:Diseases involving the fasciae]] | [[Category:Diseases involving the fasciae]] | ||
[[Category:Rheumatology]] | [[Category:Rheumatology]] | ||
[[Category:Needs overview]] | |||
{{WH}} | |||
{{WS}} | |||
Revision as of 14:21, 18 March 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]
Future or Investigational Therapies
Pain relief
Recent research indicates that cytokines, a group of chemicals that are produced by various cells in the body, may be responsible for generating the response of chronic pain associated with Rheumatoid Arthritis. Medications that affect the release of cytokines or block the action of cytokines may reduce the response of chronic pain. Various anti-cytokine medications are now being used to treat painful disease states such as Rheumatoid Arthritis, and Crohn's Disease. In addition, research using the anti-cytokine medication, Thalidomide, is being evaluated for its effect in treating chronic pain associated with Arachnoiditis. Food (vegetables) with higher water content should be avoided.
Specific desensitization
An experimental treatment known as enzyme potentiated desensitization (EPD) is now under development for the treatment of rheumatoid arthritis and other autoimmune diseases. EPD uses dilutions of allergen (in this case type 2 collagen) and an enzyme, β-glucuronidase, to which T-regulatory lymphocytes respond by favouring desensitization, rather than sensitization. Initial results are encouraging [1] but the treatment is still at an early stage of development.
Other therapies
Other therapies are weight loss, occupational therapy, podiatry, physiotherapy, joint injections, and special tools to improve hard movements (e.g. special tin-openers).
Severely affected joints may require joint replacement surgery, such as knee replacement.
References
- ↑ EPD treatment of rheumatoid arthritis proof of concept results on Epidyme website use of EPD to treat autoimmune diseases.