Splenomegaly causes: Difference between revisions

Revision as of 19:11, 22 March 2013

Less common causes ^[3]

Splenomegaly grouped on the basis of the pathogenic mechanism

Increased function	Abnormal blood flow	Infitration
Removal of defective RBCs Spherocytosis Thalassemia Hemoglobinopathies Nutritional anemias early sickle cell anemia Immune hyperplasia Response to infection (viral,bacterial,fungal,parasitic) Mononucleosis, AIDS, viral hepatitis subacute bacterial endocarditis, bacterial septicemia splenic abscess, typhoid fever brucellosis,leptospirosis, tuberculosis histoplasmosis malaria, leishmaniasis, trypanosomiasis ehrlichiosis Disordered immunoregulation Rheumatoid arthritis SLE Serum sickness Autoimmune hemolytic anemia Immune thrombocytopenia sarcoidosis drug reactions Extramedullary hematopoiesis Myelofibrosis Marrow infiltration by tumors, leukemias marrow damage by radiation, toxins	Organ Failure Cirrhosis congestive heart failure Vascular hepatic vein obstruction portal vein obstruction Budd-Chiari syndrome splenic vein obstruction Infections hepatic schistosomiasis hepatic echinococcosis	Metabolic diseases Gauchers disease Niemann-Pick disease Hurler syndrome and other Mucopolysaccharidoses Amyloidosis Tangier disease Benign and malignant infiltrations Leukemias(acute,chronic,lymphoid and myeloid) lymphomas(Hodgkins and non-hodgkins) myeloproliferative disorders metastatic tumors(commonly melanoma) histiocytosis X Hemangioma,lymphangioma splenic cysts hamartomas eosinophilic granuloma

↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
↑ Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X
↑ Kahan, Scott, Smith, Ellen G. In a page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:157

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 ===Causes of Massive Splenomegaly (>1000gms)===
 <br /><br />[[Thalassemia]]<br />[[Kala-Azar]] ([[Leishmaniasis]])<br />[[Portal hypertension]] of Bilharziasis<br />[[Chronic myelogenous leukemia]]<br />[[lymphomas]]<br />[[hairy cell leukemia]]<br />[[myelofibrosis]]<br />[[polycythemia vera]]<br />[[Gauchers disease]]<br />[[chronic lymphocytic leukemia]]<br />[[sarcoidosis]]<br />[[autoimmune hemolytic anemia]]<br />[[Malaria]]