Cardiac amyloidosis natural history, complications and prognosis: Difference between revisions
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==Complications== | ==Complications== | ||
* Congestive [[heart failure]] | * Congestive [[heart failure]] | ||
* [[Sudden cardiac death]] | |||
* [[Atrial fibrillation]] or [[ventricular arrhythmia]]s | * [[Atrial fibrillation]] or [[ventricular arrhythmia]]s | ||
* [[Sick sinus syndrome]] (occasionally) | * [[Sick sinus syndrome]] (occasionally) and [[heart block]]s | ||
* Symptomatic cardiac conduction system disease (arrhythmias related to abnormal conduction of impulses through the heart muscle) | * Symptomatic cardiac conduction system disease (arrhythmias related to abnormal conduction of impulses through the heart muscle) | ||
* Low [[blood pressure]] and dizziness from excessive urination (from medication) | * Low [[blood pressure]] and dizziness from excessive urination (from medication) | ||
* Increased sensitivity to [[digoxin]] with the potential for digoxin toxicity and related arrhythmias. The amyloid protein tends to bind the digoxin and increase its local concentration in the conduction system for instance. | * Increased sensitivity to [[digoxin]] with the potential for digoxin toxicity and related arrhythmias. The amyloid protein tends to bind the digoxin and increase its local concentration in the conduction system for instance. | ||
* [[Ascites]] (fluid accumulation in the abdomen) | * [[Ascites]] (fluid accumulation in the abdomen) | ||
* [[Cardiac tamponade]]<ref name="pmid1428240">{{cite journal |author=Navarro JF, Rivera M, Ortuño J |title=Cardiac tamponade as presentation of systemic amyloidosis |journal=[[International Journal of Cardiology]] |volume=36 |issue=1 |pages=107–8 |year=1992 |month=July |pmid=1428240 |doi= |url=}}</ref> | |||
==References== | ==References== | ||
Revision as of 17:57, 3 May 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor: Cafer Zorkun, M.D., Ph.D. [2]; Lakshmi Gopalakrishnan, M.B.B.S. [3]
Overview
The presence or absence of cardiac involvement with amyloid is the most important prognostic factor.[1]
Prognosis
Cardiac amyloidosis is a chronic and progressive condition. A cardiologist may estimate the prognosis according to the thickness of the left ventricle and to the degree of restriction in the heart (diastolic dysfunction). For primary amyloidosis, the median survival after diagnosis is about 2.1 years.
Complications
- Congestive heart failure
- Sudden cardiac death
- Atrial fibrillation or ventricular arrhythmias
- Sick sinus syndrome (occasionally) and heart blocks
- Symptomatic cardiac conduction system disease (arrhythmias related to abnormal conduction of impulses through the heart muscle)
- Low blood pressure and dizziness from excessive urination (from medication)
- Increased sensitivity to digoxin with the potential for digoxin toxicity and related arrhythmias. The amyloid protein tends to bind the digoxin and increase its local concentration in the conduction system for instance.
- Ascites (fluid accumulation in the abdomen)
- Cardiac tamponade[2]
References
- ↑ Gertz MA, Lacy MQ, Dispenzieri A (1999). "Amyloidosis: recognition, confirmation, prognosis, and therapy". Mayo Clinic Proceedings. Mayo Clinic. 74 (5): 490–4. doi:10.4065/74.5.490. PMID 10319082. Retrieved 2012-02-13. Unknown parameter
|month=ignored (help) - ↑ Navarro JF, Rivera M, Ortuño J (1992). "Cardiac tamponade as presentation of systemic amyloidosis". International Journal of Cardiology. 36 (1): 107–8. PMID 1428240. Unknown parameter
|month=ignored (help)