Cardiac amyloidosis natural history, complications and prognosis: Difference between revisions
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{{Cardiac amyloidosis}} | , {{Cardiac amyloidosis}} | ||
{{CMG}}; '''Associate Editor:''' {{AN}}; {{RT}}; {{CZ}}; {{LG}} | {{CMG}}; '''Associate Editor:''' {{AN}}; {{RT}}; {{CZ}}; {{LG}} | ||
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* [[Myocardial infarction]] | * [[Myocardial infarction]] | ||
* [[Pericardial effusion]] | * [[Pericardial effusion]] | ||
* Valvular defects | * Valvular defects, [[aortic stenosis]] being the most common followed by [[mitral regurgitation]] | ||
* [[Atrial fibrillation]] | * [[Atrial fibrillation]] | ||
* [[Tachyarrhythmia]]s | * [[Tachyarrhythmia]]s | ||
Revision as of 02:33, 5 May 2013
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Cardiac amyloidosis Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Cardiac amyloidosis natural history, complications and prognosis On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor: Aarti Narayan, M.B.B.S [2]; Raviteja Guddeti, M.B.B.S. [3]; Cafer Zorkun, M.D., Ph.D. [4]; Lakshmi Gopalakrishnan, M.B.B.S. [5]
Overview
The presence or absence of cardiac involvement with amyloid is the most important prognostic factor.[1]
Complications
- Congestive heart failure
- Sudden cardiac death
- Myocardial infarction
- Pericardial effusion
- Valvular defects, aortic stenosis being the most common followed by mitral regurgitation
- Atrial fibrillation
- Tachyarrhythmias
- Ventricular arrhythmias
- Sick sinus syndrome (occasionally)
- Heart blocks and other conduction defects
- Syncope or presyncope
- Increased sensitivity to digoxin with the potential for digoxin toxicity and related arrhythmias. The amyloid protein tends to bind the digoxin and increase its local concentration in the conduction system for instance.
- Ascites (fluid accumulation in the abdomen)
- Cardiac tamponade[2]
- Stroke and claudication due to intracardiac thrombus causing thromboembolism.
Prognosis
Cardiac amyloidosis is a chronic and progressive condition. A cardiologist may estimate the prognosis according to the thickness of the left ventricle and to the degree of restriction in the heart (diastolic dysfunction).
References
- ↑ Gertz MA, Lacy MQ, Dispenzieri A (1999). "Amyloidosis: recognition, confirmation, prognosis, and therapy". Mayo Clinic Proceedings. Mayo Clinic. 74 (5): 490–4. doi:10.4065/74.5.490. PMID 10319082. Retrieved 2012-02-13. Unknown parameter
|month=ignored (help) - ↑ Navarro JF, Rivera M, Ortuño J (1992). "Cardiac tamponade as presentation of systemic amyloidosis". International Journal of Cardiology. 36 (1): 107–8. PMID 1428240. Unknown parameter
|month=ignored (help)