Congestive heart failure and omega-3-fatty acids: Difference between revisions
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====Landmark Studies==== | ====Landmark Studies==== | ||
* A prospective cohort study in 4738 adults of >65 years without heart failure at baseline have shown that consumption of tuna and other broiled or baked fish is associated with lower incidence of heart failure, no such association is found in individuals consuming fried fish.<ref>{{cite journal |author=Mozaffarian D, Bryson CL, Lemaitre RN, Burke GL, Siscovick DS |title=Fish intake and risk of incident heart failure |journal=J. Am. Coll. Cardiol. |volume=45 |issue=12 |pages=2015–21 |year=2005 |month=June |pmid=15963403 |doi=10.1016/j.jacc.2005.03.038 |url=}}</ref> | * A prospective cohort study in 4738 adults of >65 years without heart failure at baseline have shown that consumption of tuna and other broiled or baked fish is associated with lower incidence of heart failure, no such association is found in individuals consuming fried fish.<ref>{{cite journal |author=Mozaffarian D, Bryson CL, Lemaitre RN, Burke GL, Siscovick DS |title=Fish intake and risk of incident heart failure |journal=J. Am. Coll. Cardiol. |volume=45 |issue=12 |pages=2015–21 |year=2005 |month=June |pmid=15963403 |doi=10.1016/j.jacc.2005.03.038 |url=}}</ref> | ||
* Another prospective cohort study in 2735 US adults without prevalent heart disease have shown that omega-3 fatty acid plasma concentration are associated with lower incidence of congestive heart failure in older adults.<ref> {{cite journal |author=Mozaffarian D, Lemaitre RN, King IB, ''et al.'' |title=Circulating long-chain ω-3 fatty acids and incidence of congestive heart failure in older adults: the cardiovascular health study: a cohort study |journal=Ann. Intern. Med. |volume=155 |issue=3 |pages=160–70 |year=2011 |month=August |pmid=21810709 |pmc=3371768 |doi=10.1059/0003-4819-155-3-201108020-00006 |url=}}</ref> | * Another prospective cohort study in 2735 US adults without prevalent heart disease have shown that omega-3 fatty acid plasma concentration are associated with lower incidence of congestive heart failure in older adults.<ref> {{cite journal |author=Mozaffarian D, Lemaitre RN, King IB, ''et al.'' |title=Circulating long-chain ω-3 fatty acids and incidence of congestive heart failure in older adults: the cardiovascular health study: a cohort study |journal=Ann. Intern. Med. |volume=155 |issue=3 |pages=160–70 |year=2011 |month=August |pmid=21810709 |pmc=3371768 |doi=10.1059/0003-4819-155-3-201108020-00006 |url=}}</ref> | ||
==References== | ==References== | ||
Revision as of 20:22, 7 May 2013
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Lakshmi Gopalakrishnan, M.B.B.S. [2]
Omega-3 Fatty Acid
Therapeutic Role of Omega-3 Fatty Acid in Congestive Heart Failure
Landmark Studies
The GISSI-HF Trial
- A double blind, placebo controlled trial by GISSI-HF investigator randomly assigned 6975 patients with chronic heart failure of New York Heart Association (NYHA) class II-IV to n-3 PUFA 1 g daily(n=3494) or placebo(n=3481) and were followed up for a median of 3.9 years. The study showed reduced death from any cause in n-3 PUFA group (27%) as compared to placebo group (29%). Also, the end points of deaths and admission to hospitals for cardiovascular reasons is lower in n-3 PUFA group (57%) in comparison to placebo group (59%).[1]
- A substudy of GISSI-HF trial done in 608 chronic heart failure patients indicates a small but statistically significant advantage in n-3 PUFA group in terms of LV function in symptomatic heart failure patients of any cause.[2]
Preventive Role of Omega-3 Fatty Acid in Congestive Heart Failure
Limited studies has shown the preventive role of n-3 PUFA in heart failure.
Landmark Studies
- A prospective cohort study in 4738 adults of >65 years without heart failure at baseline have shown that consumption of tuna and other broiled or baked fish is associated with lower incidence of heart failure, no such association is found in individuals consuming fried fish.[3]
- Another prospective cohort study in 2735 US adults without prevalent heart disease have shown that omega-3 fatty acid plasma concentration are associated with lower incidence of congestive heart failure in older adults.[4]
References
- ↑ Tavazzi L, Maggioni AP, Marchioli R; et al. (2008). "Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial". Lancet. 372 (9645): 1223–30. doi:10.1016/S0140-6736(08)61239-8. PMID 18757090. Unknown parameter
|month=ignored (help) - ↑ Ghio S, Scelsi L, Latini R; et al. (2010). "Effects of n-3 polyunsaturated fatty acids and of rosuvastatin on left ventricular function in chronic heart failure: a substudy of GISSI-HF trial". Eur. J. Heart Fail. 12 (12): 1345–53. doi:10.1093/eurjhf/hfq172. PMID 20952767. Unknown parameter
|month=ignored (help) - ↑ Mozaffarian D, Bryson CL, Lemaitre RN, Burke GL, Siscovick DS (2005). "Fish intake and risk of incident heart failure". J. Am. Coll. Cardiol. 45 (12): 2015–21. doi:10.1016/j.jacc.2005.03.038. PMID 15963403. Unknown parameter
|month=ignored (help) - ↑ Mozaffarian D, Lemaitre RN, King IB; et al. (2011). "Circulating long-chain ω-3 fatty acids and incidence of congestive heart failure in older adults: the cardiovascular health study: a cohort study". Ann. Intern. Med. 155 (3): 160–70. doi:10.1059/0003-4819-155-3-201108020-00006. PMC 3371768. PMID 21810709. Unknown parameter
|month=ignored (help)