Hodgkin's lymphoma natural history, complications and prognosis: Difference between revisions
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==Prognosis== | |||
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In 1998, an international effort<ref> {{cite journal | last=Hasenclever | coauthour=Diehl, et. al | title=A Prognostic Score for Advanced Hodgkin's Disease | journal=New England Journal of Medicine | volume=339 | issue=21 | date=[[1998-11-19]]}} </ref> identified seven prognostic factors that accurately predict the success rate of conventional treatment in patients with locally extensive or advanced stage Hodgkin's lymphoma. Freedom from progression (FFP) at 5 years was directly related to the number of factors present in a patient. The 5-year FFP for patients with zero factors is 84%. Each additional factor lowers the 5-year FFP rate by 7%, such that the 5-year FFP for a patient with 5 or more factors is 42%. | In 1998, an international effort<ref> {{cite journal | last=Hasenclever | coauthour=Diehl, et. al | title=A Prognostic Score for Advanced Hodgkin's Disease | journal=New England Journal of Medicine | volume=339 | issue=21 | date=[[1998-11-19]]}} </ref> identified seven prognostic factors that accurately predict the success rate of conventional treatment in patients with locally extensive or advanced stage Hodgkin's lymphoma. Freedom from progression (FFP) at 5 years was directly related to the number of factors present in a patient. The 5-year FFP for patients with zero factors is 84%. Each additional factor lowers the 5-year FFP rate by 7%, such that the 5-year FFP for a patient with 5 or more factors is 42%. | ||
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Prognosis
In 1998, an international effort[1] identified seven prognostic factors that accurately predict the success rate of conventional treatment in patients with locally extensive or advanced stage Hodgkin's lymphoma. Freedom from progression (FFP) at 5 years was directly related to the number of factors present in a patient. The 5-year FFP for patients with zero factors is 84%. Each additional factor lowers the 5-year FFP rate by 7%, such that the 5-year FFP for a patient with 5 or more factors is 42%.
The adverse prognostic factors identified in the international study are:
- Age >= 45 years
- Stage IV disease
- Hemoglobin < 10.5 g/dl
- Lymphocyte count < 600/µl or < 8%
- Male
- Albumin < 4.0 g/dl
- White blood count >= 15,000/µl
Other studies have reported the following to be the most important adverse prognostic factors: mixed-cellularity or lymphocyte-depleted histologies, male sex, large number of involved nodal sites, advanced stage, age of 40 years or more, the presence of B symptoms, high erythrocyte sedimentation rate, and bulky disease (widening of the mediastinum by more than one third, or the presence of a nodal mass measuring more than 10 cm in any dimension.)
References
- ↑ Hasenclever (1998-11-19). "A Prognostic Score for Advanced Hodgkin's Disease". New England Journal of Medicine. 339 (21). Unknown parameter
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