Dyskeratosis congenita natural history, complications and prognosis: Difference between revisions
Jump to navigation
Jump to search
Created page with "__NOTOC__ {{CMG}} ==Complications== Complications include: * Conjunctivitis, blepharitides, lacrimal duct stenosis, and pterygium * Mandibular hypoplasia, [[o..." |
No edit summary |
||
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
Please help WikiDoc by adding more content here. It's easy! Click [[help:How to Edit a Page|here]] to learn about editing. | |||
{{CMG}} | {{CMG}} | ||
Revision as of 15:56, 6 June 2013
Please help WikiDoc by adding more content here. It's easy! Click here to learn about editing.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Complications
Complications include:
- Conjunctivitis, blepharitides, lacrimal duct stenosis, and pterygium
- Mandibular hypoplasia, osteoporosis, avascular necrosis, and scoliosis.
- Cirrhosis
- Bone marrow failure - infections, bleeding
- Pulmonary fibrosis
- Dysphagia, dysuria, phimosis, and epiphora - due to constriction and stenosis can occur at the sites of leukoplakia
- Increased risk of malignancy - increased prevalence of malignant mucosal neoplasms, particularly squamous cell carcinoma of the mouth, nasopharynx, esophagus, rectum, vagina, or cervix. These often occur within sites of leukoplakia. The prevalence of squamous cell carcinoma of the skin is also increased.
- Death - due to infections, bleeding
Prognosis
Prognosis of the disease is poor with a mean survival of 30 years. Prognosis is worse for X-linked and autosomal recessive forms compared to autosomal dominant form.
References