Acrocyanosis causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ogheneochuko Ajari, MB.BS, MS [2]

Causes

Common Causes

• Idiopathic
• Arsenic poisoning
• Scleroderma
• Ethylmalonic encephalopathy

The blue discoloration that is seen in a person with acrocyanosis may also be caused by argyria or DADPS.

Causes by Organ System

Cardiovascular	Atheromatous embolism, Myocardial infarction, pulmonary hypertension, Arsenic poisoning, fucosidosis
Chemical / poisoning	Arsenic poisoning
Dermatologic	Acrocyanosis of infancy, black foot disease, fucosidosis, livedoid vasculopathy, remittent idiopathic necrotizing acrocyanosis, scleroderma, sulfhemoglobinemia, anorexia nervosa, Buerger's disease, ethylmalonic encephalopathy, waldenström macroglobulinemia Van Bogaert-Hozay syndrome, wegener's granulomatosis, arsenic poisoning
Drug Side Effect	Amphotericin B deoxycholate, butyl nitrate, imipramine, interferon 2 alpha
Ear Nose Throat	Wegener's granulomatosis, Van Bogaert-Hozay syndrome
Endocrine	No underlying causes
Environmental	Arsenic poisoning
Gastroenterologic	Ethylmalonic encephalopathy, scleroderma, fucosidosis, atheromatous embolism, anorexia nervosa, waldenström macroglobulinemia, arsenic poisoning
Genetic	Genetic
Hematologic	Antiphospholipid syndrome, cold agglutinin disease, cryoglobulinemia, essential thrombocytopenia, methemoglobinemia, secondary polycythemia, sulfhemoglobinemia, waldenström macroglobulinemia, ethylmalonic encephalopathy
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal / Ortho	Puffy hand syndrome, Van Bogaert-Hozay syndrome, fucosidosis, brachial plexus neuropathy, stroke, Buerger's disease, erythromelalgia, waldenström macroglobulinemia, antiphospholipid syndrome
Neurologic	Brachial plexus neuropathy, spinal cord injury, stroke, waldenström macroglobulinemia, ethylmalonic encephalopathy, fucosidosis, atheromatous embolism, arsenic poisoning, Van Bogaert-Hozay syndrome
Nutritional / Metabolic	Arsenic poisoning, anorexia nervosa, atheromatous embolism
Obstetric/Gynecologic	Anorexia nervosa
Oncologic	No underlying causes
Opthalmologic	Van Bogaert-Hozay syndrome, wegener's granulomatosis, atheromatous embolism, waldenström macroglobulinemia
Overdose / Toxicity	No underlying causes
Psychiatric	Anorexia nervosa, asperger disease, schizophrenia, Van Bogaert-Hozay syndrome
Pulmonary	Pulmonary alveolar proteinosis, pulmonary arteriovenous malformations, pulmonary embolism, pulmonary hypertension, scleroderma, arsenic poisoning, wegener's granulomatosis, waldenström macroglobulinemia
Renal / Electrolyte	Atheromatous embolism, wegener's granulomatosis, scleroderma, waldenström macroglobulinemia
Rheum / Immune / Allergy	Buerger's disease, erythromelalgia, wegener's granulomatosis, antiphospholipid syndrome
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Dental	Wegener's granulomatosis
Miscellaneous	Idiopathic, black foot disease

Causes in Alphabetical Order

• Acrocyanosis of infancy
• Amphotericin B deoxycholate
• Anorexia nervosa
• Antiphospholipid syndrome
• Arsenic poisoning
• Asperger disease
• Atheromatous embolism
• Black foot disease
• Brachial plexus neuropathy
• Buerger's disease
• Butyl nitrate
• Cold agglutinin disease
• Cryoglobulinemia
• Erythromelalgia
• Essential thrombocytopenia
• Ethylmalonic encephalopathy
• Fucosidosis
• Genetic
• Idiopathic
• Imipramine
• Interferon 2 alpha
• Livedoid vasculopathy
• Methemoglobinemia
• Myocardial infarction
• Puffy hand syndrome
• Pulmonary alveolar proteinosis
• Pulmonary arteriovenous malformations
• Pulmonary embolism
• Pulmonary hypertension
• Remittent idiopathic necrotizing acrocyanosis
• Schizophrenia
• Scleroderma
• Secondary polycythemia
• Spinal cord injury
• Stroke
• Sulfhemoglobinemia
• Van Bogaert-Hozay syndrome
• Waldenström macroglobulinemia
• Wegener's granulomatosis