Leukocyte alkaline phosphatase: Difference between revisions

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{|style="width:82%; height:100px" border="1"
{|style="width:82%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | [[Atrial fibrillation]], [[Giant cell arteritis]], [[Hemorrhagic shock]], [[Ischemic colitis]], [[Myocardial infarction]], [[Pericarditis]], [[Subacute endocarditis]], [[Vasculitis]]
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | [[Atrial fibrillation]], [[giant cell arteritis]], [[hemorrhagic shock]], [[ischemic colitis]], [[myocardial infarction]], [[pericarditis]], [[subacute endocarditis]], [[vasculitis]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Chemical/Poisoning'''
| '''Chemical/Poisoning'''
|bgcolor="Beige"| [[Camphor]], [[Lead]], [[Lithium]], [[Mercury]], [[Pyrogallol]], [[Snakebite]], [[Turpentine]]
|bgcolor="Beige"| [[Camphor]], [[lead]], [[lithium]], [[mercury]], [[pyrogallol]], [[snakebite]], [[turpentine]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
| '''Drug Side Effect'''
|bgcolor="Beige"| [[All-trans retinoic acid]], [[Arsphenamine]], [[Catecholamines ]], [[Corticosteroids]], [[Dapsone]], [[Digitalis]], [[Neuroleptic malignant syndrome]], [[Oral contraceptives]], [[Phenacetin]], [[Quinidine]], [[Sulfa drugs]]
|bgcolor="Beige"| [[All-trans retinoic acid]], [[arsphenamine]], [[catecholamines ]], [[corticosteroids]], [[dapsone]], [[digitalis]], [[neuroleptic malignant syndrome]], [[oral contraceptives]], [[phenacetin]], [[quinidine]], [[sulfa drugs]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Endocrine'''
| '''Endocrine'''
|bgcolor="Beige"| [[Cushing disease]], [[Diabetes]], [[Diabetic coma]], [[Diabetic ketoacidosis]]
|bgcolor="Beige"| [[Cushing's disease]], [[diabetes]], [[diabetic coma]], [[diabetic ketoacidosis]]
|-  
|-  
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
| '''Gastroenterologic'''
|bgcolor="Beige"| [[Appendicitis]], [[Cholangitis]], [[Cholecystitis]], [[Gastric carcinoma]], [[Hepatic necrosis]], [[Ischemic colitis]], [[Liver abscess]], [[Liver fluke]]
|bgcolor="Beige"| [[Appendicitis]], [[chholangitis]], [[cholecystitis]], [[gastric carcinoma]], [[fulminant hepatic necrosis]], [[ischemic colitis]], [[liver abscess]], [[liver fluke]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Genetic'''
| '''Genetic'''
|bgcolor="Beige"| [[Congenital Asplenia]], [[Congenital neutropenia ]], [[Down syndrome]], [[Familial cold autoinflammatory syndrome]], [[Fanconi anemia]], [[Hereditary neutrophilia]], [[Hyposplenism]], [[Klinefelter syndrome]], [[Kostmann's syndrome]], [[Leukocyte adhesion factor deficiency]], [[Pelger-huet anomaly]], [[Rac mutation]]
|bgcolor="Beige"| [[Congenital Asplenia]], [[congenital neutropenia ]], [[down syndrome]], [[familial cold autoinflammatory syndrome]], [[Fanconi anemia]], [[hereditary neutrophilia]], [[hyposplenism]], [[Klinefelter syndrome]], [[Kostmann's syndrome]], [[leukocyte adhesion factor deficiency]], [[Pelger-Huet anomaly]], [[rac mutation]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Hematologic'''
| '''Hematologic'''
|bgcolor="Beige"| [[Acute lymphoblastic leukemia]], [[Acute myelogenous leukemia]], [[Agnogenic myeloid metaplasia]], [[Aplastic anemia]], *[[chronic neutrophilic leukemia]], [[Essential thrombocytopenia]], [[Fanconi anemia]], [[Hairy cell leukemia]], [[Hemarthrosis]], [[Hemolysis]], [[Hemoperitoneum]], [[Hemorrhagic shock]], [[Hodgkin's lymphoma]], [[Infectious mononucleosis ]], [[Megaloblastic anemia]], [[Multiple myeloma]], [[Myelofibrosis]], [[Pelger-huet anomaly]], [[Polycythemia vera]]
|bgcolor="Beige"| [[Acute lymphoblastic leukemia]], [[acute myelogenous leukemia]], [[agnogenic myeloid metaplasia]], [[aplastic anemia]], [[chronic neutrophilic leukemia]], [[essential thrombocytopenia]], [[Fanconi anemia]], [[hairy cell leukemia]], [[hemarthrosis]], [hemolysis]], [[hemoperitoneum]], [[hemorrhagic shock]], [[Hodgkin's lymphoma]], [[infectious mononucleosis ]], [[megaloblastic anemia]], [[multiple myeloma]], [[myelofibrosis]], [[Pelger-Huet anomaly]], [[polycythemia vera]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Iatrogenic'''
| '''Iatrogenic'''
|bgcolor="Beige"| [[Blood transfusion]], [[G-CSF]], [[GM-CSF]], [[Post spleenectomy ]], [[Vaccination ]]
|bgcolor="Beige"| [[Blood transfusion]], [[G-CSF]], [[GM-CSF]], [[splenectomy|post splenectomy ]], [[vaccination ]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Infectious Disease'''
| '''Infectious Disease'''
|bgcolor="Beige"| [[Actinomyces]], [[Burkholderia mallei ]], [[Cellulitis]], [[Cholangitis]], [[Cholecystitis]], [[Clostridium difficile]], [[Coccidioides immitis]], [[Escherichia coli]], [[Herpes zoster]], [[Infectious mononucleosis ]], [[Klebsiella pneumoniae ]], [[Liver abscess]], [[Liver fluke]], [[Malaria]], [[Mycobacterium tuberculosis ]], [[Neisseria gonorrhoeae]], [[Osteomyelitis]], [[Otitis media]], [[Pelvic abscess]], [[Pelvic inflammatory disease]], [[Perinephric abscess]], [[Pertussis]], [[Plague]], [[Poliomyelitis]], [[Pseudomonas aeruginosa]], [[Pyelonephritis]], [[Rabies]], [[Rheumatic disease]], [[Rickettsia]], [[Salmonella typhi]], [[Salpingitis]], [[Sepsis]], [[Septic arthritis]], [[Smallpox]], [[Spirochetes]], [[Staphylococcus aureus]], [[Staphylococcus epidermidis]], [[Streptococcus pneumoniae]], [[Streptococcus pyogenes]], [[Subacute endocarditis]], [[Tonsillitis]], [[Varicella]], [[Visceral larva migrans ]]
|bgcolor="Beige"| [[Actinomyces]], [[burkholderia mallei ]], [[cellulitis]], [[cholangitis]], [[cholecystitis]], [[clostridium difficile]], [[coccidioides immitis]], [[escherichia coli]], [[herpes zoster]], [[infectious mononucleosis ]], [[klebsiella pneumoniae ]], [[liver abscess]], [[liver fluke]], [[malaria]], [[mycobacterium tuberculosis ]], [[neisseria gonorrhoeae]], [[osteomyelitis]], [[otitis media]], [[pelvic abscess]], [[pelvic inflammatory disease]], [[perinephric abscess]], [[pertussis]], [[plague]], [[poliomyelitis]], [[pseudomonas aeruginosa]], [[pyelonephritis]], [[rabies]], [[rheumatic disease]], [[rickettsia]], [[salmonella typhi]], [salpingitis]], [[sepsis]], [[septic arthritis]], [[smallpox]], [[spirochetes]], [[staphylococcus aureus]], [[staphylococcus epidermidis]], [[streptococcus pneumoniae]], [[streptococcus pyogenes]], [[subacute endocarditis]], [[tonsillitis]], [[varicella]], [[visceral larva migrans ]]
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Musculoskeletal/Orthopedic'''
| '''Musculoskeletal/Orthopedic'''
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Neurologic'''
| '''Neurologic'''
|bgcolor="Beige"| [[Eclampsia]], [[Epidural hemorrhage]], [[Intra cerebral hemorrhage]], [[Pre eclampsia]], [[Subdural hemorrhage]]
|bgcolor="Beige"| [[Eclampsia]], [[epidural hemorrhage]], [[intracerebral hemorrhage]], [[preeclampsia]], [[subdural hemorrhage]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
| '''Nutritional/Metabolic'''
|bgcolor="Beige"| [[Diabetic coma]], [[Diabetic ketoacidosis]], [[Uremia]]
|bgcolor="Beige"| [[Diabetic coma]], [[diabetic ketoacidosis]], [[uremia]]
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
| '''Obstetric/Gynecologic'''
|bgcolor="Beige"| [[Cesarean delivery]], [[Eclampsia]], [[Pelvic inflammatory disease]], [[Preeclampsia]], [[Pregnancy]], [[Salpingitis]]
|bgcolor="Beige"| [[Cesarean delivery]], [eclampsia]], [[pelvic inflammatory disease]], [[preeclampsia]], [[pregnancy]], [[salpingitis]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Oncologic'''
| '''Oncologic'''
|bgcolor="Beige"| [[Acute lymphoblastic leukemia]], [[Acute myelogenous leukemia]], [[Agnogenic myeloid metaplasia]], [[Bronchogenic carcinoma ]], [[Gastric carcinoma]], [[Hairy cell leukemia]], [[Hodgkin's lymphoma]], [[Paraneoplastic phenomenon ]], [[Renal carcinoma]], [[Squamous cell carcinoma]]
|bgcolor="Beige"| [[Acute lymphoblastic leukemia]], [[acute myelogenous leukemia]], [[agnogenic myeloid metaplasia]], [[bronchogenic carcinoma ]], [[gastric carcinoma]], [[hairy cell leukemia]], [[Hodgkin's lymphoma]], [[paraneoplastic phenomenon ]], [[renal carcinoma]], [[squamous cell carcinoma]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Psychiatric'''
| '''Psychiatric'''
|bgcolor="Beige"| [[Chronic anxiety state]], [[Depression]], [[Panic disorders]], [[Posttraumatic stress disorder]]
|bgcolor="Beige"| [[Chronic anxiety state]], [[depression]], [[panic disorders]], [[posttraumatic stress disorder]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Pulmonary'''
| '''Pulmonary'''
|bgcolor="Beige"| [[Bronchogenic carcinoma ]], [[Hemoperitoneum]], [[Klebsiella pneumoniae ]]
|bgcolor="Beige"| [[Bronchogenic carcinoma ]], [[hemoperitoneum]], [[klebsiella pneumoniae ]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
| '''Renal/Electrolyte'''
|bgcolor="Beige"| [[Perinephric abscess]], [[Pyelonephritis]], [[Renal carcinoma]], [[Renal insufficiency]]
|bgcolor="Beige"| [[Perinephric abscess]], [[pyelonephritis]], [[renal carcinoma]], [[renal insufficiency]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
| '''Rheumatology/Immunology/Allergy'''
|bgcolor="Beige"| [[Acute gout]], [[Giant cell arteritis]], [[Rheumatic disease]], [[Rheumatoid arthritis]], [[Vasculitis]]
|bgcolor="Beige"| [[Acute gout]], [[giant cell arteritis]], [[rheumatic disease]], [[rheumatoid arthritis]], [[vasculitis]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Trauma'''
| '''Trauma'''
|bgcolor="Beige"| [[Burns]], [[Epidural hemorrhage]], [[Hemarthrosis]], [[Hemoperitoneum]], [[Intra cerebral hemorrhage]], [[Major tissue injury]], [[Subdural hemorrhage]]
|bgcolor="Beige"| [[Burns]], [[epidural hemorrhage]], [[hemarthrosis]], [[hemoperitoneum]], [[intracerebral hemorrhage]], [[,ajor tissue injury]], [[subdural hemorrhage]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Miscellaneous'''
| '''Miscellaneous'''
|bgcolor="Beige"| [[Chronic idiopathic neutrophilia]], [[Cigarette smoking]], [[Emotional stress]], [[Insect venoms]], [[Physical stress]], [[Vigorous exercise]]
|bgcolor="Beige"| [[Chronic idiopathic neutrophilia]], [cigarette smoking]], [[emotional stress]], [[insect venoms]], [[physical stress]], [[vigorous exercise]]
|-
|-
|}
|}

Revision as of 14:57, 17 July 2013

Leukocyte alkaline phosphatase

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Experimental / Informatics

List of terms related to Leukocyte alkaline phosphatase

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Vendhan Ramanujam M.B.B.S [2]

Synonyms and keywords: LAP

Overview

Leukocyte alkaline phosphatase is an enzyme found within white blood cells. The blood level of leukocyte alkaline phosphatase is measured in order to help in the diagnosis of certain conditions. Higher levels of the enzyme are seen in polycythemia vera, essential thrombocytosis, primary myelofibrosis and leukemoid reaction. Lower levels are found in chronic myelogenous leukemia, aplastic anemia, paroxysmal nocturnal hemoglobinuria and acute myelogenous leukemia.

Causes of Increased Leukocyte Alkaline Phosphatase

Common Causes

Causes by Organ System

Cardiovascular Atrial fibrillation, giant cell arteritis, hemorrhagic shock, ischemic colitis, myocardial infarction, pericarditis, subacute endocarditis, vasculitis
Chemical/Poisoning Camphor, lead, lithium, mercury, pyrogallol, snakebite, turpentine
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect All-trans retinoic acid, arsphenamine, catecholamines , corticosteroids, dapsone, digitalis, neuroleptic malignant syndrome, oral contraceptives, phenacetin, quinidine, sulfa drugs
Ear Nose Throat Tonsillitis
Endocrine Cushing's disease, diabetes, diabetic coma, diabetic ketoacidosis
Environmental Heatstroke
Gastroenterologic Appendicitis, chholangitis, cholecystitis, gastric carcinoma, fulminant hepatic necrosis, ischemic colitis, liver abscess, liver fluke
Genetic Congenital Asplenia, congenital neutropenia , down syndrome, familial cold autoinflammatory syndrome, Fanconi anemia, hereditary neutrophilia, hyposplenism, Klinefelter syndrome, Kostmann's syndrome, leukocyte adhesion factor deficiency, Pelger-Huet anomaly, rac mutation
Hematologic Acute lymphoblastic leukemia, acute myelogenous leukemia, agnogenic myeloid metaplasia, aplastic anemia, chronic neutrophilic leukemia, essential thrombocytopenia, Fanconi anemia, hairy cell leukemia, hemarthrosis, [hemolysis]], hemoperitoneum, hemorrhagic shock, Hodgkin's lymphoma, infectious mononucleosis , megaloblastic anemia, multiple myeloma, myelofibrosis, Pelger-Huet anomaly, polycythemia vera
Iatrogenic Blood transfusion, G-CSF, GM-CSF, post splenectomy , vaccination
Infectious Disease Actinomyces, burkholderia mallei , cellulitis, cholangitis, cholecystitis, clostridium difficile, coccidioides immitis, escherichia coli, herpes zoster, infectious mononucleosis , klebsiella pneumoniae , liver abscess, liver fluke, malaria, mycobacterium tuberculosis , neisseria gonorrhoeae, osteomyelitis, otitis media, pelvic abscess, pelvic inflammatory disease, perinephric abscess, pertussis, plague, poliomyelitis, pseudomonas aeruginosa, pyelonephritis, rabies, rheumatic disease, rickettsia, salmonella typhi, [salpingitis]], sepsis, septic arthritis, smallpox, spirochetes, staphylococcus aureus, staphylococcus epidermidis, streptococcus pneumoniae, streptococcus pyogenes, subacute endocarditis, tonsillitis, varicella, visceral larva migrans
Musculoskeletal/Orthopedic Septic arthritis
Neurologic Eclampsia, epidural hemorrhage, intracerebral hemorrhage, preeclampsia, subdural hemorrhage
Nutritional/Metabolic Diabetic coma, diabetic ketoacidosis, uremia
Obstetric/Gynecologic Cesarean delivery, [eclampsia]], pelvic inflammatory disease, preeclampsia, pregnancy, salpingitis
Oncologic Acute lymphoblastic leukemia, acute myelogenous leukemia, agnogenic myeloid metaplasia, bronchogenic carcinoma , gastric carcinoma, hairy cell leukemia, Hodgkin's lymphoma, paraneoplastic phenomenon , renal carcinoma, squamous cell carcinoma
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric Chronic anxiety state, depression, panic disorders, posttraumatic stress disorder
Pulmonary Bronchogenic carcinoma , hemoperitoneum, klebsiella pneumoniae
Renal/Electrolyte Perinephric abscess, pyelonephritis, renal carcinoma, renal insufficiency
Rheumatology/Immunology/Allergy Acute gout, giant cell arteritis, rheumatic disease, rheumatoid arthritis, vasculitis
Sexual No underlying causes
Trauma Burns, epidural hemorrhage, hemarthrosis, hemoperitoneum, intracerebral hemorrhage, ,ajor tissue injury, subdural hemorrhage
Urologic No underlying causes
Miscellaneous Chronic idiopathic neutrophilia, [cigarette smoking]], emotional stress, insect venoms, physical stress, vigorous exercise

Causes in Alphabetical Order

Causes of Decreased Leukocyte Alkaline Phosphatase[4][5]

Common Causes

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect No underlying causes
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic No underlying causes
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order

References

  1. ↑ Brook J, Dreisbach PB (1977). "Leukocyte alkaline phosphatase levels in multiple myeloma". J Lab Clin Med. 90 (1): 114–7. PMID 406335.
  2. ↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  3. ↑ Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X
  4. ↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  5. ↑ Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X


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