Leukocyte alkaline phosphatase: Difference between revisions
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*[[Essential thrombocytosis]] | *[[Essential thrombocytosis]] | ||
*[[Leukemoid reaction]] | *[[Leukemoid reaction]] | ||
*[[Malignant lymphoma]] | *[[Malignant lymphoma]] | ||
*[[Megaloblastic anemia]] | *[[Megaloblastic anemia]] | ||
*[[Multiple Myeloma]]<ref name="pmid406335">{{cite journal| author=Brook J, Dreisbach PB| title=Leukocyte alkaline phosphatase levels in multiple myeloma. | journal=J Lab Clin Med | year= 1977 | volume= 90 | issue= 1 | pages= 114-7 | pmid=406335 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=406335 }} </ref> | *[[Multiple Myeloma]]<ref name="pmid406335">{{cite journal| author=Brook J, Dreisbach PB| title=Leukocyte alkaline phosphatase levels in multiple myeloma. | journal=J Lab Clin Med | year= 1977 | volume= 90 | issue= 1 | pages= 114-7 | pmid=406335 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=406335 }} </ref> | ||
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| '''Iatrogenic''' | | '''Iatrogenic''' | ||
|bgcolor="Beige"| [[Blood transfusion]], [[G-CSF]], [[GM-CSF]], [[splenectomy|post | |bgcolor="Beige"| [[Blood transfusion]], [[G-CSF]], [[GM-CSF]], [[splenectomy|post spleenectomy]], [[vaccination ]] | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
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|-bgcolor="LightSteelBlue" | |-bgcolor="LightSteelBlue" | ||
| '''Pulmonary''' | | '''Pulmonary''' | ||
|bgcolor="Beige"| [[Bronchogenic carcinoma]], [[hemoperitoneum]], [[klebsiella pneumoniae ]] | |bgcolor="Beige"| [[Bronchogenic carcinoma]], [[hemoperitoneum]], [[klebsiella pneumoniae]] | ||
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*[[Hodgkin's lymphoma]] | *[[Hodgkin's lymphoma]] | ||
*[[Hyposplenism]] | *[[Hyposplenism]] | ||
*[[Infectious mononucleosis ]] | *[[Infectious mononucleosis]] | ||
*Insect venoms | *Insect venoms | ||
*[[Intracerebral hemorrhage]] | *[[Intracerebral hemorrhage]] | ||
*[[Ischemic colitis]] | *[[Ischemic colitis]] | ||
*[[Klebsiella pneumoniae ]] | *[[Klebsiella pneumoniae]] | ||
*[[Klinefelter syndrome]] | *[[Klinefelter syndrome]] | ||
*[[Kostmann syndrome]] | *[[Kostmann syndrome]] | ||
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*[[Mercury]] | *[[Mercury]] | ||
*[[Multiple myeloma]] | *[[Multiple myeloma]] | ||
*[[Mycobacterium tuberculosis ]] | *[[Mycobacterium tuberculosis]] | ||
*[[Myelofibrosis]] | *[[Myelofibrosis]] | ||
*[[Myocardial infarction]] | *[[Myocardial infarction]] | ||
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*[[Poliomyelitis]] | *[[Poliomyelitis]] | ||
*[[Polycythemia vera]] | *[[Polycythemia vera]] | ||
*[[Splenectomy|Post splenectomy ]] | *[[Splenectomy|Post splenectomy]] | ||
*[[Posttraumatic stress disorder]] | *[[Posttraumatic stress disorder]] | ||
*[[Preeclampsia]] | *[[Preeclampsia]] | ||
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*[[Atherosclerotic heart disease]] | *[[Atherosclerotic heart disease]] | ||
*[[Atopic dermatitis]] | *[[Atopic dermatitis]] | ||
*[[Chronic myelogenous leukemia | Atypical chronic myelogenous leukemia ]] | *[[Chronic myelogenous leukemia | Atypical chronic myelogenous leukemia]] | ||
*[[Bacterial overgrowth]] | *[[Bacterial overgrowth]] | ||
*[[Bariatric surgery]] | *[[Bariatric surgery]] | ||
Revision as of 16:39, 18 July 2013
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Vendhan Ramanujam M.B.B.S [2]
Synonyms and keywords: LAP
Overview
Leukocyte alkaline phosphatase is an enzyme found within white blood cells. The blood level of leukocyte alkaline phosphatase is measured in order to help in the diagnosis of certain conditions. Higher levels of the enzyme are seen in polycythemia vera, essential thrombocytosis, primary myelofibrosis and leukemoid reaction. Lower levels are found in chronic myelogenous leukemia, aplastic anemia, paroxysmal nocturnal hemoglobinuria and acute myelogenous leukemia.
Causes of Increased Leukocyte alkaline phosphatase
Common Causes
- Acute leukemia
- Essential thrombocytosis
- Leukemoid reaction
- Malignant lymphoma
- Megaloblastic anemia
- Multiple Myeloma[1]
- Myelofibrosis
- Polycythemia Vera
- Solid tumors
- Tissue necrosis[2][3]
Causes by Organ System
Causes in Alphabetical Order
Causes of Decreased Leukocyte alkaline phosphatase
Common Causes
- Aplastic anemia
- Chronic Myelogenous Leukemia
- Hypophosphatemia[4]
- Iron deficiency anemia
- Paroxysmal nocturnal hemoglobinuria
- Systemic lupus erythematosus[5][6][7][8][9]
Causes by Organ System
Causes in Alphabetical Order
References
- ↑ Brook J, Dreisbach PB (1977). "Leukocyte alkaline phosphatase levels in multiple myeloma". J Lab Clin Med. 90 (1): 114–7. PMID 406335.
- ↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
- ↑ Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X
- ↑ Gaasbeek, A.; Meinders, AE. (2005). "Hypophosphatemia: an update on its etiology and treatment". Am J Med. 118 (10): 1094–101. doi:10.1016/j.amjmed.2005.02.014. PMID 16194637. Unknown parameter
|month=ignored (help) - ↑ TANAKA, KR.; VALENTINE, WN.; FREDRICKS, RE. (1960). "Diseases or clinical conditions associated with low leukocyte alkaline phosphatase". N Engl J Med. 262: 912–8. doi:10.1056/NEJM196005052621804. PMID 13836802. Unknown parameter
|month=ignored (help) - ↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
- ↑ Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X
- ↑ 8.0 8.1 Sharma, SC. (1980). "Leucocyte alkaline phosphatase in neonatal infections". Postgrad Med J. 56 (657): 485–7. PMID 7443603. Unknown parameter
|month=ignored (help) - ↑ 9.0 9.1 Lokich, JJ. (1977). "Leukocyte alkaline phosphatase activity in patients with malignant disease". Cancer. 40 (3): 1202–5. PMID 902237. Unknown parameter
|month=ignored (help)