Neonatal lupus erythematosus: Difference between revisions
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{{SI}} | {{SI}} | ||
'''For patient information, click [[ | '''For patient information, click [[neonatal lupus erythematosus (patient information)|here]]''' | ||
{{CMG}} | {{CMG}} | ||
{{SK}} | {{SK}}; NL; NLE; NLS, neonatal lupus; neonatal lupus syndrome | ||
== Overview == | == Overview == | ||
Neonatal lupus is a passively transferred autoimmune disease. It occurs in about 1 to 2 percent of babies born to mothers with autoimmune disease, primarily systemic lupus erythematosus (SLE) and Sjögren’s syndrome, and antibodies to SSA/Ro and/or SSB/La. The most serious complication of neonatal lupus is complete heart block. | |||
==Historical Perspective== | ==Historical Perspective== | ||
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== Pathophysiology== | == Pathophysiology== | ||
Neonatal lupus is presumed to result from transplacental passage of maternal anti-SSA/Ro and/or anti-SSB/La antibodies. Ro and La molecules are thought to form a single particle that is present in all cells. The precise mechanism of injury to specific tissues, such as the skin and heart, is not known. | |||
=== Genetics === | === Genetics === | ||
Revision as of 18:38, 26 August 2013
For patient information, click here
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords:; NL; NLE; NLS, neonatal lupus; neonatal lupus syndrome
Overview
Neonatal lupus is a passively transferred autoimmune disease. It occurs in about 1 to 2 percent of babies born to mothers with autoimmune disease, primarily systemic lupus erythematosus (SLE) and Sjögren’s syndrome, and antibodies to SSA/Ro and/or SSB/La. The most serious complication of neonatal lupus is complete heart block.
Historical Perspective
Classification
Pathophysiology
Neonatal lupus is presumed to result from transplacental passage of maternal anti-SSA/Ro and/or anti-SSB/La antibodies. Ro and La molecules are thought to form a single particle that is present in all cells. The precise mechanism of injury to specific tissues, such as the skin and heart, is not known.
Genetics
Associated Conditions
Gross Pathology
Microscopic Pathology
For patient information, click Insert page name here
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]
Synonyms and keywords: