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(Created page with "{{WBRQuestion |QuestionAuthor={{M.P}} |ExamType=USMLE Step 3 |MainCategory=Emergency Room |SubCategory=Endocrine |MainCategory=Emergency Room |SubCategory=Endocrine |MainCateg...") |
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|QuestionAuthor={{M.P}} | |QuestionAuthor={{M.P}} | ||
|ExamType=USMLE Step 3 | |ExamType=USMLE Step 3 | ||
|SubCategory=Endocrine | |SubCategory=Endocrine | ||
|SubCategory=Endocrine | |SubCategory=Endocrine | ||
|SubCategory=Endocrine | |SubCategory=Endocrine | ||
|SubCategory=Endocrine | |SubCategory=Endocrine | ||
|SubCategory=Endocrine | |SubCategory=Endocrine | ||
|SubCategory=Endocrine | |SubCategory=Endocrine | ||
|SubCategory=Endocrine | |SubCategory=Endocrine | ||
|SubCategory=Endocrine | |SubCategory=Endocrine | ||
|Prompt=A 60 yr old woman is brought to the emergency department following a motor vehicle accident. She was hit by car from her side and claims that she did not see the car coming towards her. She had a past history of intraabdominal operation done 15 yrs ago for Cushing’s syndrome. Physical examination shows tanned female with normal vital signs. She has few abrasions on her face and chest. Her injuries are managed appropriately. What is the most likely diagnosis at this point? | |Prompt=A 60 yr old woman is brought to the emergency department following a motor vehicle accident. She was hit by car from her side and claims that she did not see the car coming towards her. She had a past history of intraabdominal operation done 15 yrs ago for Cushing’s syndrome. Physical examination shows tanned female with normal vital signs. She has few abrasions on her face and chest. Her injuries are managed appropriately. What is the most likely diagnosis at this point? | ||
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D. Nelson’s syndrome | D. Nelson’s syndrome | ||
E. Empty sella syndrome | E. Empty sella syndrome | ||
|Explanation=Pituitary enlargement and hyperpigmentation following bilateral adrenalectomy is called Nelson’s syndrome. The cause of pituitary enlargement is loss of feedback by adrenal [[glucocorticoids]] following the adrenalectomy. The tumour is aggressive and is treated by surgery or pituitary radiation. Following B/L adrenalectomy prophylactic pituitary radiation is an option, but however it leads to pan [[hypopituitarinism]]. Previously treatment of Cushing’s disease is B/L adrenalectomy, but now days transphenoidal surgery is preferred. | |||
|Explanation=Pituitary enlargement and hyperpigmentation following bilateral adrenalectomy is called Nelson’s syndrome. The cause of pituitary enlargement is loss of feedback by adrenal glucocorticoids following the adrenalectomy. The tumour is aggressive and is treated by surgery or pituitary radiation. Following B/L adrenalectomy prophylactic pituitary radiation is an option, but however it leads to pan hypopituitarinism. Previously treatment of Cushing’s disease is B/L adrenalectomy, but now days transphenoidal surgery is preferred. | |||
|AnswerA=Craniopharyngioma | |AnswerA=Craniopharyngioma | ||
|AnswerAExp='''Incorrect''' : Although craniopharyngioma occurs in adults, it is uncommon at this stage. They present with hypopituitarism and diabetes insipidus is common and hyperpigmentation does not occur in this. | |AnswerAExp='''Incorrect''' : Although [[craniopharyngioma]] occurs in adults, it is uncommon at this stage. They present with hypopituitarism and [[diabetes insipidus]] is common and hyperpigmentation does not occur in this. | ||
|AnswerB=Prolactinoma | |AnswerB=Prolactinoma | ||
|AnswerBExp='''Incorrect''' : Prolactinoma causes infertility, oligomenorrhea, or amenorrhea. Galactorrhea, gynecomastia, or bitemporal hemianopia maybe prominent. But hyperpigmentation does not occur. | |AnswerBExp='''Incorrect''' : [[Prolactinoma]] causes infertility, oligomenorrhea, or amenorrhea. Galactorrhea, gynecomastia, or bitemporal hemianopia maybe prominent. But hyperpigmentation does not occur. | ||
|AnswerC=Brain tumour | |AnswerC=Brain tumour | ||
|AnswerCExp='''Incorrect''' : Only parasellar and intrasellar meningioma produce visual field defects and not other. Hyperpigmentation is not a finding. | |AnswerCExp='''Incorrect''' : Only parasellar and intrasellar [[meningioma]] produce visual field defects and not other. Hyperpigmentation is not a finding. | ||
|AnswerD=Nelson’s syndrome | |AnswerD=Nelson’s syndrome | ||
|AnswerDExp='''Correct''' : Pituitary enlargement and hyperpigmentation following bilateral adrenalectomy is called Nelson’s syndrome | |AnswerDExp='''Correct''' : Pituitary enlargement and hyperpigmentation following bilateral adrenalectomy is called Nelson’s syndrome | ||
|AnswerE=Empty sella syndrome | |AnswerE=Empty sella syndrome | ||
|AnswerEExp='''Incorrect''' : Hyperpigmentation and visual field defects does not occur in empty sella syndrome | |AnswerEExp='''Incorrect''' : Hyperpigmentation and visual field defects does not occur in [[empty sella syndrome]] | ||
|RightAnswer=D | |RightAnswer=D | ||
|Approved=Yes | |Approved=Yes | ||
}} | }} | ||
Revision as of 15:35, 30 August 2013
| Author | [[PageAuthor::Mugilan Poongkunran M.B.B.S [1]]] |
|---|---|
| Exam Type | ExamType::USMLE Step 3 |
| Main Category | |
| Sub Category | SubCategory::Endocrine |
| Prompt | [[Prompt::A 60 yr old woman is brought to the emergency department following a motor vehicle accident. She was hit by car from her side and claims that she did not see the car coming towards her. She had a past history of intraabdominal operation done 15 yrs ago for Cushing’s syndrome. Physical examination shows tanned female with normal vital signs. She has few abrasions on her face and chest. Her injuries are managed appropriately. What is the most likely diagnosis at this point?
A. Craniopharyngioma B. Prolactinoma C. Brain tumour D. Nelson’s syndrome E. Empty sella syndrome]] |
| Answer A | AnswerA::Craniopharyngioma |
| Answer A Explanation | [[AnswerAExp::Incorrect : Although craniopharyngioma occurs in adults, it is uncommon at this stage. They present with hypopituitarism and diabetes insipidus is common and hyperpigmentation does not occur in this.]] |
| Answer B | AnswerB::Prolactinoma |
| Answer B Explanation | [[AnswerBExp::Incorrect : Prolactinoma causes infertility, oligomenorrhea, or amenorrhea. Galactorrhea, gynecomastia, or bitemporal hemianopia maybe prominent. But hyperpigmentation does not occur.]] |
| Answer C | AnswerC::Brain tumour |
| Answer C Explanation | [[AnswerCExp::Incorrect : Only parasellar and intrasellar meningioma produce visual field defects and not other. Hyperpigmentation is not a finding.]] |
| Answer D | AnswerD::Nelson’s syndrome |
| Answer D Explanation | AnswerDExp::'''Correct''' : Pituitary enlargement and hyperpigmentation following bilateral adrenalectomy is called Nelson’s syndrome |
| Answer E | AnswerE::Empty sella syndrome |
| Answer E Explanation | [[AnswerEExp::Incorrect : Hyperpigmentation and visual field defects does not occur in empty sella syndrome]] |
| Right Answer | RightAnswer::D |
| Explanation | [[Explanation::Pituitary enlargement and hyperpigmentation following bilateral adrenalectomy is called Nelson’s syndrome. The cause of pituitary enlargement is loss of feedback by adrenal glucocorticoids following the adrenalectomy. The tumour is aggressive and is treated by surgery or pituitary radiation. Following B/L adrenalectomy prophylactic pituitary radiation is an option, but however it leads to pan hypopituitarinism. Previously treatment of Cushing’s disease is B/L adrenalectomy, but now days transphenoidal surgery is preferred. Educational Objective: |
| Approved | Approved::Yes |
| Keyword | |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |