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Created page with "{{WBRQuestion |QuestionAuthor=William J Gibson |ExamType=USMLE Step 1 |MainCategory=Biochemistry, Genetics |SubCategory=General Principles |MainCategory=Biochemistry, Genetics..." |
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|MainCategory=Biochemistry, Genetics | |MainCategory=Biochemistry, Genetics | ||
|SubCategory=General Principles | |SubCategory=General Principles | ||
|Prompt=A 25 year old girl presents to her primary care physician complaining of generalized weakness. She reports that the weakness is particularly pronounced in her hands, feet and neck. Furthermore, she reports some difficulty swallowing the multivitamins she takes daily. On further questioning, she admits to greater than normal daytime sleepiness. Past medical history significant is only for occasional gastrointestinal distress over the past 5 years. The young woman reports 3 sexual partners in the last six months. The physician notes that the patient was unable to release her grip after shaking hands. Which of the following techniques would allow a pathologist to confirm the diagnosis from a sample of the patient’s DNA? | |||
|AnswerA=Northern blot; 5’(CAG){{sub|n}}3’ probe | |||
|AnswerB=Northern blot; 5’(CTG){{sub|n}}3’ probe | |||
|AnswerC=Southern blot; 5’(CAG){{sub|n}}3’ probe | |||
|AnswerD=Southern blot; 5’(CTG){{sub|n}}3’ probe | |||
|AnswerE=Southern blot; 5’(CAA){{sub|n}}3’ probe | |||
|Approved=No | |Approved=No | ||
}} | }} | ||
Revision as of 12:51, 5 September 2013
| Author | PageAuthor::William J Gibson |
|---|---|
| Exam Type | ExamType::USMLE Step 1 |
| Main Category | MainCategory::Biochemistry, MainCategory::Genetics |
| Sub Category | SubCategory::General Principles |
| Prompt | [[Prompt::A 25 year old girl presents to her primary care physician complaining of generalized weakness. She reports that the weakness is particularly pronounced in her hands, feet and neck. Furthermore, she reports some difficulty swallowing the multivitamins she takes daily. On further questioning, she admits to greater than normal daytime sleepiness. Past medical history significant is only for occasional gastrointestinal distress over the past 5 years. The young woman reports 3 sexual partners in the last six months. The physician notes that the patient was unable to release her grip after shaking hands. Which of the following techniques would allow a pathologist to confirm the diagnosis from a sample of the patient’s DNA?]] |
| Answer A | [[AnswerA::Northern blot; 5’(CAG)n3’ probe]] |
| Answer A Explanation | AnswerAExp:: |
| Answer B | [[AnswerB::Northern blot; 5’(CTG)n3’ probe]] |
| Answer B Explanation | AnswerBExp:: |
| Answer C | [[AnswerC::Southern blot; 5’(CAG)n3’ probe]] |
| Answer C Explanation | AnswerCExp:: |
| Answer D | [[AnswerD::Southern blot; 5’(CTG)n3’ probe]] |
| Answer D Explanation | AnswerDExp:: |
| Answer E | [[AnswerE::Southern blot; 5’(CAA)n3’ probe]] |
| Answer E Explanation | AnswerEExp:: |
| Right Answer | RightAnswer:: |
| Explanation | [[Explanation:: Educational Objective: |
| Approved | Approved::No |
| Keyword | |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |