Leopard syndrome epidemiology and demographics: Difference between revisions
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==Overview== | ==Overview== | ||
Leopaed syndrome is a rare condition, but the exact birth prevalence is unknown. Not less than 200 patients have been reported and two reviews published.<ref name="pmid1258892">{{cite journal| author=Voron DA, Hatfield HH, Kalkhoff RK| title=Multiple lentigines syndrome. Case report and review of the literature. | journal=Am J Med | year= 1976 | volume= 60 | issue= 3 | pages= 447-56 | pmid=1258892 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1258892 }} </ref> However, Leopard syndrome is likely underdiagnosed or misdiagnosed as many of its features are mild and the correct diagnosis might be missed in the absence of [[lentiginosis]]. | Leopaed syndrome is a rare condition, but the exact birth prevalence is unknown. Not less than 200 patients have been reported and two reviews published.<ref name="pmid1258892">{{cite journal| author=Voron DA, Hatfield HH, Kalkhoff RK| title=Multiple lentigines syndrome. Case report and review of the literature. | journal=Am J Med | year= 1976 | volume= 60 | issue= 3 | pages= 447-56 | pmid=1258892 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1258892 }} </ref> However, Leopard syndrome is likely underdiagnosed or misdiagnosed as many of its features are mild and the correct diagnosis might be missed in the absence of [[lentiginosis]]. | ||
==Overview== | |||
There is no epidemiologic data available regarding how many in the world population suffer from the syndrome, however there are slightly over 200 cases described in medical literature. | |||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
Various literature describes it as being rare.<ref>{{cite web |url=http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=LEOPARD%20Syndrome |title=NORD - National Organization for Rare Disorders, Inc. |accessdate=2008-01-20 |format= |work=}}</ref> There is no epidemiologic data available regarding how many in the world population suffer from the syndrome, however there are slightly over 200 cases described in medical literature. Within the group of the so called 'neuro-cardio-facial-cutaneous' syndromes, Leopard syndrome is probably the second most common disorder after [[Noonan syndrome]].<ref name="pmid16520774">{{cite journal| author=Bentires-Alj M, Kontaridis MI, Neel BG| title=Stops along the RAS pathway in human genetic disease. | journal=Nat Med | year= 2006 | volume= 12 | issue= 3 | pages= 283-5 | pmid=16520774 | doi=10.1038/nm0306-283 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16520774 }} </ref> | Various literature describes it as being rare.<ref>{{cite web |url=http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=LEOPARD%20Syndrome |title=NORD - National Organization for Rare Disorders, Inc. |accessdate=2008-01-20 |format= |work=}}</ref> There is no epidemiologic data available regarding how many in the world population suffer from the syndrome, however there are slightly over 200 cases described in medical literature. Within the group of the so called 'neuro-cardio-facial-cutaneous' syndromes, Leopard syndrome is probably the second most common disorder after [[Noonan syndrome]].<ref name="pmid16520774">{{cite journal| author=Bentires-Alj M, Kontaridis MI, Neel BG| title=Stops along the RAS pathway in human genetic disease. | journal=Nat Med | year= 2006 | volume= 12 | issue= 3 | pages= 283-5 | pmid=16520774 | doi=10.1038/nm0306-283 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16520774 }} </ref> | ||
===Age=== | |||
Lentigines may be present at birth or develop during childhood, they become more numerous and darker with age. | |||
===Gender=== | |||
Slightly increased prevalence in men has been documented. | |||
===Race=== | |||
Leopard syndrome has no clear racial predilection. | |||
==References== | ==References== | ||
Revision as of 16:39, 6 September 2013
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Leopard syndrome Microchapters |
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Treatment |
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Case Studies |
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Leopard syndrome epidemiology and demographics On the Web |
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American Roentgen Ray Society Images of Leopard syndrome epidemiology and demographics |
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Risk calculators and risk factors for Leopard syndrome epidemiology and demographics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]
Overview
Leopaed syndrome is a rare condition, but the exact birth prevalence is unknown. Not less than 200 patients have been reported and two reviews published.[1] However, Leopard syndrome is likely underdiagnosed or misdiagnosed as many of its features are mild and the correct diagnosis might be missed in the absence of lentiginosis.
Overview
There is no epidemiologic data available regarding how many in the world population suffer from the syndrome, however there are slightly over 200 cases described in medical literature.
Epidemiology and Demographics
Various literature describes it as being rare.[2] There is no epidemiologic data available regarding how many in the world population suffer from the syndrome, however there are slightly over 200 cases described in medical literature. Within the group of the so called 'neuro-cardio-facial-cutaneous' syndromes, Leopard syndrome is probably the second most common disorder after Noonan syndrome.[3]
Age
Lentigines may be present at birth or develop during childhood, they become more numerous and darker with age.
Gender
Slightly increased prevalence in men has been documented.
Race
Leopard syndrome has no clear racial predilection.
References
- ↑ Voron DA, Hatfield HH, Kalkhoff RK (1976). "Multiple lentigines syndrome. Case report and review of the literature". Am J Med. 60 (3): 447–56. PMID 1258892.
- ↑ "NORD - National Organization for Rare Disorders, Inc". Retrieved 2008-01-20.
- ↑ Bentires-Alj M, Kontaridis MI, Neel BG (2006). "Stops along the RAS pathway in human genetic disease". Nat Med. 12 (3): 283–5. doi:10.1038/nm0306-283. PMID 16520774.