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|SubCategory=Oncology | |SubCategory=Oncology | ||
|Prompt=A 12-year-old boy comes to the health center because he has had persistent fever and pain in his right leg for the past 2 months. He says that he recently added jogging to his weight-lifting workouts, and he started running 5 miles per day 2 weeks ago. He is 5 ft 7 inches tall and weighs 60kg. On physical examination, he has moderate tenderness over the diaphysis of the right leg. Additional tests were done which revealed a small, round, blue cell tumor, and a translocation between chromosomes 11 and 22. X-ray of the hip will most likely show which of the following? | |Prompt=A 12-year-old boy comes to the health center because he has had persistent fever and pain in his right leg for the past 2 months. He says that he recently added jogging to his weight-lifting workouts, and he started running 5 miles per day 2 weeks ago. He is 5 ft 7 inches tall and weighs 60kg. On physical examination, he has moderate tenderness over the diaphysis of the right leg. Additional tests were done which revealed a small, round, blue cell tumor, and a translocation between chromosomes 11 and 22. X-ray of the hip will most likely show which of the following? | ||
|Explanation=Ewing’s sarcoma is a malignant small, round, blue cell tumor in which cancer cells are found in the bone or in soft biological tissue. It is a rare disease commonly prevalent among boys less than 15 years of age. The most common locations are: pelvis, femur, humerus, ribs and clavicle (collar bone). The characteristic appearance on X-ray is the “Onion-skin” appearance. Treatment is chemotherapy. | |Explanation=Ewing’s sarcoma is a malignant small, round, blue cell tumor in which cancer cells are found in the bone or in soft biological tissue. It is a rare disease commonly prevalent among boys less than 15 years of age. The most common locations are: pelvis, femur, humerus, ribs and clavicle (collar bone). The characteristic appearance on X-ray is the “Onion-skin” appearance. Treatment is chemotherapy. | ||
|AnswerA=“Double bubble” sign | |AnswerA=“Double bubble” sign | ||
|AnswerAExp=Double bubble sign is a feature of Osteoclastoma. The age range is between 20-40 years and it is usually located at the epiphysis of long bones. | |AnswerAExp=Incorrect. Double bubble sign is a feature of Osteoclastoma. The age range is between 20-40 years and it is usually located at the epiphysis of long bones. | ||
|AnswerB=Codman’s triangle or sunburst appearance pattern | |AnswerB=Codman’s triangle or sunburst appearance pattern | ||
|AnswerBExp=This is a feature of Osteosarcoma. It affects men between ages 10-20 years. It is usually around the metaphysis of long bones. | |AnswerBExp=Incorrect. This is a feature of Osteosarcoma. It affects men between ages 10-20 years. It is usually around the metaphysis of long bones. | ||
|AnswerC=“Onion-skin” appearance | |AnswerC=“Onion-skin” appearance | ||
|AnswerCExp=The “Onion-skin” appearance is a pathognomonic feature observed in Ewing's sarcoma. | |AnswerCExp=Correct. The “Onion-skin” appearance is a pathognomonic feature observed in Ewing's sarcoma. | ||
|AnswerD=Glistering mass within the medullary cavity | |AnswerD=Glistering mass within the medullary cavity | ||
|AnswerDExp=This is a feature of Chondrosarcoma. It affects men between the ages 30-60. It is commonly found in the pelvis, spine, scapula, tibia, and femur. | |AnswerDExp=Incorrect. This is a feature of Chondrosarcoma. It affects men between the ages 30-60. It is commonly found in the pelvis, spine, scapula, tibia, and femur. | ||
|AnswerE=Normal findings | |AnswerE=Normal findings | ||
|AnswerEExp=The presence of a small, round, blue cell tumor, and a translocation between chromosomes 11 and 22 are not normal in any individual. | |AnswerEExp=Incorrect. The presence of a small, round, blue cell tumor, and a translocation between chromosomes 11 and 22 are not normal in any individual. | ||
|RightAnswer=C | |RightAnswer=C | ||
|Approved=Yes | |Approved=Yes | ||
}} | }} | ||
Revision as of 12:23, 9 September 2013
| Author | [[PageAuthor::Ayokunle Olubaniyi, M.B,B.S [1]]] |
|---|---|
| Exam Type | ExamType::USMLE Step 1 |
| Main Category | MainCategory::Pathology |
| Sub Category | SubCategory::Oncology |
| Prompt | [[Prompt::A 12-year-old boy comes to the health center because he has had persistent fever and pain in his right leg for the past 2 months. He says that he recently added jogging to his weight-lifting workouts, and he started running 5 miles per day 2 weeks ago. He is 5 ft 7 inches tall and weighs 60kg. On physical examination, he has moderate tenderness over the diaphysis of the right leg. Additional tests were done which revealed a small, round, blue cell tumor, and a translocation between chromosomes 11 and 22. X-ray of the hip will most likely show which of the following?]] |
| Answer A | AnswerA::“Double bubble” sign |
| Answer A Explanation | AnswerAExp::Incorrect. Double bubble sign is a feature of Osteoclastoma. The age range is between 20-40 years and it is usually located at the epiphysis of long bones. |
| Answer B | AnswerB::Codman’s triangle or sunburst appearance pattern |
| Answer B Explanation | AnswerBExp::Incorrect. This is a feature of Osteosarcoma. It affects men between ages 10-20 years. It is usually around the metaphysis of long bones. |
| Answer C | AnswerC::“Onion-skin” appearance |
| Answer C Explanation | AnswerCExp::Correct. The “Onion-skin” appearance is a pathognomonic feature observed in Ewing's sarcoma. |
| Answer D | AnswerD::Glistering mass within the medullary cavity |
| Answer D Explanation | AnswerDExp::Incorrect. This is a feature of Chondrosarcoma. It affects men between the ages 30-60. It is commonly found in the pelvis, spine, scapula, tibia, and femur. |
| Answer E | AnswerE::Normal findings |
| Answer E Explanation | AnswerEExp::Incorrect. The presence of a small, round, blue cell tumor, and a translocation between chromosomes 11 and 22 are not normal in any individual. |
| Right Answer | RightAnswer::C |
| Explanation | [[Explanation::Ewing’s sarcoma is a malignant small, round, blue cell tumor in which cancer cells are found in the bone or in soft biological tissue. It is a rare disease commonly prevalent among boys less than 15 years of age. The most common locations are: pelvis, femur, humerus, ribs and clavicle (collar bone). The characteristic appearance on X-ray is the “Onion-skin” appearance. Treatment is chemotherapy. Educational Objective: |
| Approved | Approved::Yes |
| Keyword | |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |