DEFINE Trial: Difference between revisions

	High Density Lipoprotein Microchapters
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Revision as of 12:35, 18 September 2013

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Objective

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 {{CMG}}
-==Overview==
-* Various clinical trials<ref name="pmid19781408">{{cite journal |author=Cannon CP, Dansky HM, Davidson M, ''et al.'' |title=Design of the DEFINE trial: determining the EFficacy and tolerability of CETP INhibition with AnacEtrapib |journal=[[American Heart Journal]] |volume=158 |issue=4 |pages=513–519.e3 |year=2009 |month=October |pmid=19781408 |doi=10.1016/j.ahj.2009.07.028 |url=}}</ref><ref name="pmid18068514">{{cite journal |author=Krishna R, Anderson MS, Bergman AJ, ''et al.'' |title=Effect of the cholesteryl ester transfer protein inhibitor, anacetrapib, on lipoproteins in patients with dyslipidaemia and on 24-h ambulatory blood pressure in healthy individuals: two double-blind, randomised placebo-controlled phase I studies |journal=[[Lancet]] |volume=370 |issue=9603 |pages=1907–14 |year=2007 |month=December |pmid=18068514 |doi=10.1016/S0140-6736(07)61813-3 |url=}}</ref> showed that [[anacetrapib]] significantly lowers [[LDL]] cholesterol and raises [[HDL]] levels without any increase in [[systolic blood pressure]].
+==Objective==
+==Timeline==
+==Methods==
+==Results==
+==Conclusion==
 ==References==
 {{Reflist|2}}

v t e Lipopedia
Basic Science	Cholesterol • Triglyceride Lipoprotein metabolism and transport Lipoprotein: Chylomicron • Chylomicron remnant • HDL • IDL • LDL • Lipoprotein(a) • VLDL • Lipoprotein-X Apolipoprotein: APOA (1, 2, 4, 5) • APOB ( Apolipoprotein B-48, Apolipoprotein B-100) • APOC (1, 2, 3, 4) • APOD • APOE • APOH • APOJ • APOL • APOM • Apo(a) Lipoprotein receptor: LDL receptor • Soluble low density lipoprotein receptor-related protein (sLRP) • Apolipoprotein E Receptor 2 • Scavenger receptor • Scavenger receptor A • Scavenger receptor B • VLDL receptor Lipoprotein enzymes: Lipoprotein lipase • Lipoprotein-associated phospholipase A2 (Lp-PLA2) • Cholesterylester transfer protein ( Acetyl-CoA C-acyltransferase, Lecithin-cholesterol acyltransferase) • Microsomal triglyceride transfer protein • ABCA1 Genes: Low density lipoprotein receptor gene family • Microsomal triglyceride transfer protein • ABCA1
Lipoprotein Disorders	Lipoprotein disorders Primary lipoprotein disorders: Familial hyperchylomicronemia (Type I) • Familial hypercholesterolemia (Type IIA) • Familial combined hyperlipidemia (Type IIB) • Dysbetalipoproteinemia (Type III) • Primary hypertriglyceridemia (Type IV) • Mixed hyperlipoproteinemia (Type V) Secondary lipoprotein disorders
Abnormal Laboratory Lipid Profile	Low chylomicron • Low chylomicron remnant • Low HDL • Low IDL • Low LDL • Low lipoprotein(a) • Low VLDL High chylomicron • High chylomicron remnant • High HDL • High IDL • High LDL • High Lipoprotein(a) • High VLDL

DEFINE Trial: Difference between revisions

Revision as of 12:35, 18 September 2013

Objective

Timeline

Methods

Results

Conclusion

References

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