High density lipoprotein future or investigational therapies: Difference between revisions
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==De-lipidated HDL Infusions== | ==De-lipidated HDL Infusions== | ||
==HDL Mimetics== | ==HDL Mimetics== | ||
===ApoA- | ===ApoA-1 Mimetic Peptides=== | ||
* D-4F and L-4F | * D-4F and L-4F | ||
===ATI-5261 Synthetic Peptide=== | ===ATI-5261 Synthetic Peptide=== | ||
===Endothelial Lipase Inhibitors=== | ===Endothelial Lipase Inhibitors=== | ||
===LCAT Modulators=== | ===LCAT Modulators=== | ||
==Endocannabinoid Receptor Blockers== | ==Endocannabinoid Receptor Blockers== | ||
==ApoA-I Upregulators== | ==ApoA-I Upregulators== | ||
Revision as of 20:01, 19 September 2013
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High Density Lipoprotein Microchapters |
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Treatment |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The Need
The importance of increasing serum levels and functionality of HDL-C in lowering residual cardiovascular risks in patients with acute coronary syndromes cannot be over-emphasized. First of all, some recent studies reported failures of orally active medications that increase serum levels of HDL-C to potentially improve cardiovascular outcomes, such as niacin in the AIM-HIGH Trial. This have shifted the focus of researchers to other targets of HDL therapy aimed at increasing the serum levels of HDL as well as its functionality i.e., cellular cholesterol efflux and HDL-mediated reverse cholesterol transport mechanisms. Secondly, since the available oral medications elevate HDL over weeks to months, there is the need for medications which rapidly improve outcomes during acute vascular events.
Direct Infusion of Apo A-1
This involves the reconstituted and the recombinant preparations.
ApoA-1 Milano
CSL-112
CER-001
Cholesterol Ester Transfer Protein (CETP) Inhibition
CETi-1 Vaccine
JTT-705
De-lipidated HDL Infusions
HDL Mimetics
ApoA-1 Mimetic Peptides
- D-4F and L-4F