High cholesterol causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]

Overview

Elevated cholesterol level can be caused by a wide variety of factors which include: genetic (e.g. familial hypercholesterolemia); endocrine (e.g. diabetes mellitus ); drug side effect (e.g. beta blockers, thiazide diuretics); kidney disease (e.g. nephrotic syndrome, chronic kidney disease), and many other factors.

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. High cholesterol in itself is not a life threatening condition.

Common Causes

• Beta blockers
• Binge eating disorder
• Corticosteroids
• Diabetes mellitus
• Estrogens
• Familial hypercholesterolemia
• Hypothyroidism
• Metabolic syndrome
• Nephrotic syndrome
• Obesity
• Pregnancy
• Thiazide diuretics

Causes by Organ System

Cardiovascular	Alagille syndrome, familial hypercholesterolemia
Chemical/Poisoning	No underlying causes
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	Estrogens, everolimus, olanzapine, sirolimus, temsirolimus, thiazide diuretics , tofacitinib
Ear Nose Throat	No underlying causes
Endocrine	Diabetes mellitus, hypothyroidism, metabolic syndrome, polycystic ovary syndrome
Environmental	No underlying causes
Gastroenterologic	Glycogenosis type 3, glycogenosis type 6, Niemann-Pick disease type B , primary biliary cirrhosis, Stauffer syndrome, Zieve's syndrome
Genetic	Analbuminaemia, apo A-I deficiency, apolipoprotein B deficiency, Apolipoprotein C2 deficiency, apoliprotein E deficiency, autosomal recessive hypercholesterolemia, familial combined hyperlipidemia, familial hypercholesterolemia, familial hyperlipoproteinemia type 5, glycogen storage disease type 1a, glycogenosis type 3, glycogenosis type 6, lecithin cholesterol acyltransferase deficiency, lipoprotein lipase deficiency, Niemann-Pick disease type B
Hematologic	Zieve's syndrome
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal/Orthopedic	Berardinelli–Seip syndrome
Neurologic	Apo A-I deficiency, apoliprotein E deficiency
Nutritional/Metabolic	Analbuminaemia, Berardinelli–Seip syndrome, diabetes mellitus, glycogenosis type 3, glycogenosis type 6, metabolic syndrome, Niemann-Pick disease type B, obesity, Zieve's syndrome
Obstetric/Gynecologic	Polycystic ovary syndrome, pregnancy
Oncologic	No underlying causes
Ophthalmologic	Alström syndrome
Overdose/Toxicity	No underlying causes
Psychiatric	Binge eating disorder
Pulmonary	No underlying causes
Renal/Electrolyte	Chronic kidney disease, nephrotic syndrome
Rheumatology/Immunology/Allergy	Hashimoto's thyroiditis
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	Lack of physical inactivity

Causes in Alphabetical Order

• Apo A-I deficiency
• Alagille syndrome
• Alström syndrome
• Analbuminaemia
• Antiretroviral therapy
• Apolipoprotein B deficiency
• Apolipoprotein C2 deficiency
• Apoliprotein E deficiency
• Autosomal recessive hypercholesterolemia
• Beta blockers
• Binge eating disorder
• Berardinelli–Seip syndrome
• Chronic kidney disease
• Corticosteroids
• Cyclosporine

• Diabetes mellitus
• Estrogens
• Everolimus
• Familial combined hyperlipidemia
• Familial hypercholesterolemia
• Familial hyperlipoproteinemia type 5
• Glycogen storage disease type 1a
• Glycogenosis type 3
• Glycogenosis type 6
• Hypothyroidism
• Hypothyroidism
• Hashimoto's thyroiditis
• Lack of physical activity
• Lecithin cholesterol acyltransferase deficiency
• Lipoprotein lipase deficiency

• Metabolic syndrome
• Nephrotic syndrome
• Niemann-Pick disease type B
• Obesity
• Olanzapine
• Polycystic ovary syndrome
• Pregnancy
• Primary biliary cirrhosis
• Sirolimus
• Temsirolimus
• Thiazide diuretics
• Tofacitinib
• Zieve's syndrome

References

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