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|QuestionAuthor=[[User:Gonzalo Romero|Gonzalo A. Romero, M.D.]] [mailto:gromero@wikidoc.org] | |QuestionAuthor=[[User:Gonzalo Romero|Gonzalo A. Romero, M.D.]] [mailto:gromero@wikidoc.org] | ||
|ExamType=USMLE Step 1 | |ExamType=USMLE Step 1 | ||
|MainCategory=Pharmacology | |MainCategory=Pharmacology, Physiology | ||
|SubCategory=Endocrine, Reproductive | |SubCategory=Endocrine, Reproductive | ||
|MainCategory=Pharmacology | |MainCategory=Pharmacology, Physiology | ||
|SubCategory=Endocrine, Reproductive | |SubCategory=Endocrine, Reproductive | ||
|MainCategory=Pharmacology | |MainCategory=Pharmacology, Physiology | ||
|SubCategory=Endocrine, Reproductive | |SubCategory=Endocrine, Reproductive | ||
|MainCategory=Pharmacology | |MainCategory=Pharmacology, Physiology | ||
|MainCategory=Pharmacology | |MainCategory=Pharmacology, Physiology | ||
|SubCategory=Endocrine, Reproductive | |SubCategory=Endocrine, Reproductive | ||
|MainCategory=Pharmacology | |MainCategory=Pharmacology, Physiology | ||
|SubCategory=Endocrine, Reproductive | |SubCategory=Endocrine, Reproductive | ||
|MainCategory=Pharmacology | |MainCategory=Pharmacology, Physiology | ||
|SubCategory=Endocrine, Reproductive | |SubCategory=Endocrine, Reproductive | ||
|MainCategory=Pharmacology | |MainCategory=Pharmacology, Physiology | ||
|SubCategory=Endocrine, Reproductive | |SubCategory=Endocrine, Reproductive | ||
|MainCategory=Pharmacology | |MainCategory=Pharmacology, Physiology | ||
|MainCategory=Pharmacology | |MainCategory=Pharmacology, Physiology | ||
|SubCategory=Endocrine, Reproductive | |SubCategory=Endocrine, Reproductive | ||
|Prompt=A pharmacist is eager to study different models in reproductive pharmacology. He is very passionate about translational research. He is planning a study with mice in order to determine the effects of a novel drug called “Pharma-WBR”. He knows that the drug is supposed to work in the hypothalamus, to regulate the release of different pituitary hormones. He measures serum concentration and determines that the drug causes different changes in FSH and LH if used continuously or pulsatile. He finds analogy of a drug existing in the market. Which of the following drugs has a similar mechanism of action as “Pharma-WBR”? | |Prompt=A pharmacist is eager to study different models in reproductive pharmacology. He is very passionate about translational research. He is planning a study with mice in order to determine the effects of a novel drug called “Pharma-WBR”. He knows that the drug is supposed to work in the hypothalamus, to regulate the release of different pituitary hormones. He measures serum concentration and determines that the drug causes different changes in FSH and LH if used continuously or pulsatile. He finds analogy of a drug existing in the market. Which of the following drugs has a similar mechanism of action as “Pharma-WBR”? | ||
|Explanation=<font color="MediumBlue"><font size="4">'''Educational Objective:''' </font></font> | |Explanation=Leuprolide is a [[GnRH ]] analog. If used in pulsatile fashion, it acts as an agonist. If used continuously, it acts as an antagonist, because it downregulates the GnRH receptor in pituitary, therefore decreasing FSH and LH. It is used continuously with flutamide to treat prostatic cancer or uterine fibroids. It is used pulsatile in cases of infertility. | ||
# | <font color="MediumBlue"><font size="4">'''Educational Objective:''' </font></font> | ||
# Leuprolide is a GrRH analog, which acts on the pituitary. | |||
# If used continously it decreases FSH and LH. If used in a pulsatile fashion it increases FSH and LH levels. | |||
[[File:Pituitary Phys.png|center|600px]]<br> | [[File:Pituitary Phys.png|center|600px]]<br> | ||
'''References:''' | '''References:''' | ||
First Aid 2012 for Step 1, Reproductive-Pharmacology chapter. | |||
|AnswerA=Flutamide | |AnswerA=Flutamide | ||
|AnswerAExp=<font color="red">'''Incorrect.'''</font> [[Flutamide]] is a nonsteroidal competitive inhibitor of androgens at the testosterone receptor used in | |||
prostate cancer. | |||
|AnswerAExp=<font color="red">'''Incorrect.'''</font> | |||
|AnswerB=Finasteride | |AnswerB=Finasteride | ||
|AnswerBExp=<font color="red">'''Incorrect.'''</font> [[Finasteride]] is a 5 alfa-reductase inhibitor used to treat BPH and male-pattern baldness. | |||
|AnswerC=Mifepristone | |||
|AnswerC= | |AnswerCExp=<font color="red">'''Incorrect.'''</font> [[Mifepristone]] is a competitive inhibitor of progestins at the progesterone receptors. It is used to terminate pregnancy in combination with [[misoprostol]] (PGE1 analog). | ||
|AnswerCExp=<font color="red">'''Incorrect.'''</font> | |||
|AnswerD=Ketoconazol | |AnswerD=Ketoconazol | ||
|AnswerDExp=<font color="red">'''Incorrect.'''</font> | |AnswerDExp=<font color="red">'''Incorrect.'''</font> | ||
|AnswerE=Leuprolide | |AnswerE=Leuprolide | ||
|AnswerEExp=<font color="Green">'''Correct.'''</font> | |AnswerEExp=<font color="Green">'''Correct.'''</font> See overall explanation. | ||
|RightAnswer=E | |RightAnswer=E | ||
|WBRKeyword=Pituitary hormones | |WBRKeyword=Pituitary hormones | ||
|Approved=No | |Approved=No | ||
}} | }} | ||
Revision as of 15:58, 25 September 2013
| Author | [[PageAuthor::Gonzalo A. Romero, M.D. [1]]] |
|---|---|
| Exam Type | ExamType::USMLE Step 1 |
| Main Category | MainCategory::Pharmacology, MainCategory::Physiology |
| Sub Category | SubCategory::Endocrine, SubCategory::Reproductive |
| Prompt | [[Prompt::A pharmacist is eager to study different models in reproductive pharmacology. He is very passionate about translational research. He is planning a study with mice in order to determine the effects of a novel drug called “Pharma-WBR”. He knows that the drug is supposed to work in the hypothalamus, to regulate the release of different pituitary hormones. He measures serum concentration and determines that the drug causes different changes in FSH and LH if used continuously or pulsatile. He finds analogy of a drug existing in the market. Which of the following drugs has a similar mechanism of action as “Pharma-WBR”?]] |
| Answer A | AnswerA::Flutamide |
| Answer A Explanation | [[AnswerAExp::Incorrect. Flutamide is a nonsteroidal competitive inhibitor of androgens at the testosterone receptor used in
prostate cancer.]] |
| Answer B | AnswerB::Finasteride |
| Answer B Explanation | [[AnswerBExp::Incorrect. Finasteride is a 5 alfa-reductase inhibitor used to treat BPH and male-pattern baldness.]] |
| Answer C | AnswerC::Mifepristone |
| Answer C Explanation | [[AnswerCExp::Incorrect. Mifepristone is a competitive inhibitor of progestins at the progesterone receptors. It is used to terminate pregnancy in combination with misoprostol (PGE1 analog).]] |
| Answer D | AnswerD::Ketoconazol |
| Answer D Explanation | [[AnswerDExp::Incorrect.]] |
| Answer E | AnswerE::Leuprolide |
| Answer E Explanation | [[AnswerEExp::Correct. See overall explanation.]] |
| Right Answer | RightAnswer::E |
| Explanation | [[Explanation::Leuprolide is a GnRH analog. If used in pulsatile fashion, it acts as an agonist. If used continuously, it acts as an antagonist, because it downregulates the GnRH receptor in pituitary, therefore decreasing FSH and LH. It is used continuously with flutamide to treat prostatic cancer or uterine fibroids. It is used pulsatile in cases of infertility.
Educational Objective:
 References:
First Aid 2012 for Step 1, Reproductive-Pharmacology chapter. |
| Approved | Approved::No |
| Keyword | WBRKeyword::Pituitary hormones |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |