IgA nephropathy historical perspective: Difference between revisions

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==Overview==
==Overview==
==Historical Perspective==
==Historical Perspective==
Heberden first described the disease in 1801 in a 5-year-old child with abdominal pain, [[hematuria]], [[hematochezia]], and purpura of the legs. In 1837, Johann Schönlein described a syndrome of purpura associated with joint pain and urinary precipitates in children. Eduard Henoch, a student of Schönlein's, further associated abdominal pain and renal involvement with the syndrome. Jean Berger and Hinglais, in 1968, were the first to describe IgA deposition in this form of [[glomerulonephritis]] (hence, Berger’s disease): Berger J, Hinglais N. ''Les depots intercapillaires d'IgA-IgG''. J Urol Nephrol 1968;74:694-5.
          Normal  0          false  false  false    EN-US  JA  X-NONE                                                                                                                                                                                                                                                                                                                                                                      IgA nephropathy was first described by Jean Berger, a pathologist, and Nicole Hinglais, an electron microscopist, in 1968 in France.<ref name="pmid4107073">{{cite journal| author=Berger J| title=IgA glomerular deposits in renal disease. | journal=Transplant Proc | year= 1969 | volume= 1 | issue= 4 | pages= 939-44 | pmid=4107073 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4107073 }} </ref><ref name="pmid4180586">{{cite journal| author=Berger J, Hinglais N| title=[Intercapillary deposits of IgA-IgG]. | journal=J Urol Nephrol (Paris) | year= 1968 | volume= 74 | issue= 9 | pages= 694-5 | pmid=4180586 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4180586 }} </ref><ref name="pmid21705126">{{cite journal| author=Feehally J, Cameron JS| title=IgA nephropathy: progress before and since Berger. | journal=Am J Kidney Dis | year= 2011 | volume= 58 | issue= 2 | pages= 310-9 | pmid=21705126 | doi=10.1053/j.ajkd.2011.03.024 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21705126 }} </ref> In the original one-page article titled “Les depots intercapillaires d'IgA-IgG” in the “journal d’Urologie-Nephrologie”, the authors describe the renal disease under light microscopy showing focal and segmental mesangial proliferation with expansion of the matrix. Under electron microscopy, they noted the predominance of IgA deposits in the renal mesangium that were associated with the presence of less significant presence of IgG and C3. The association of IgA nephropathy with Henoch-Schonlein purpura was made very shortly by Berger following the first description of IgA nephropathy in 1969.<ref name="pmid4107073">{{cite journal| author=Berger J| title=IgA glomerular deposits in renal disease. | journal=Transplant Proc | year= 1969 | volume= 1 | issue= 4 | pages= 939-44 | pmid=4107073 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4107073 }} </ref>


==References==
==References==

Revision as of 14:35, 21 October 2013

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Historical Perspective

         Normal  0          false  false  false    EN-US  JA  X-NONE                                                                                                                                                                                                                                                                                                                                                                       IgA nephropathy was first described by Jean Berger, a pathologist, and Nicole Hinglais, an electron microscopist, in 1968 in France.[1][2][3] In the original one-page article titled “Les depots intercapillaires d'IgA-IgG” in the “journal d’Urologie-Nephrologie”, the authors describe the renal disease under light microscopy showing focal and segmental mesangial proliferation with expansion of the matrix. Under electron microscopy, they noted the predominance of IgA deposits in the renal mesangium that were associated with the presence of less significant presence of IgG and C3. The association of IgA nephropathy with Henoch-Schonlein purpura was made very shortly by Berger following the first description of IgA nephropathy in 1969.[1]

References

  1. 1.0 1.1 Berger J (1969). "IgA glomerular deposits in renal disease". Transplant Proc. 1 (4): 939–44. PMID 4107073.
  2. Berger J, Hinglais N (1968). "[Intercapillary deposits of IgA-IgG]". J Urol Nephrol (Paris). 74 (9): 694–5. PMID 4180586.
  3. Feehally J, Cameron JS (2011). "IgA nephropathy: progress before and since Berger". Am J Kidney Dis. 58 (2): 310–9. doi:10.1053/j.ajkd.2011.03.024. PMID 21705126.

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