Alport syndrome pathophysiology: Difference between revisions
Jump to navigation
Jump to search
Rim Halaby (talk | contribs) |
Rim Halaby (talk | contribs) |
||
Line 5: | Line 5: | ||
==Overview== | ==Overview== | ||
==Pathophysiology== | ==Pathophysiology== | ||
Alport’s syndrome is characterized by the defect of alpha chains of type IV collagen that constitute a triad of manifestations: renal, auditory, and ocular. Involvement of the glomerular basement membrane is the hallmark of Alport’s syndrome.<ref name="pmid8154501">{{cite journal| author=Bodziak KA, Hammond WS, Molitoris BA| title=Inherited diseases of the glomerular basement membrane. | journal=Am J Kidney Dis | year= 1994 | volume= 23 | issue= 4 | pages= 605-18 | pmid=8154501 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8154501 }} </ref><ref name="pmid8238007">{{cite journal| author=Kashtan CE, Michael AF| title=Alport syndrome: from bedside to genome to bedside. | journal=Am J Kidney Dis | year= 1993 | volume= 22 | issue= 5 | pages= 627-40 | pmid=8238007 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8238007 }} </ref> It is still controversial as to whether the basement membrane becomes thicker or thinner to induce splitting. | |||
==References== | ==References== |
Revision as of 16:23, 31 October 2013
Alport syndrome Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Alport syndrome pathophysiology On the Web |
American Roentgen Ray Society Images of Alport syndrome pathophysiology |
Risk calculators and risk factors for Alport syndrome pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Alport’s syndrome is characterized by the defect of alpha chains of type IV collagen that constitute a triad of manifestations: renal, auditory, and ocular. Involvement of the glomerular basement membrane is the hallmark of Alport’s syndrome.[1][2] It is still controversial as to whether the basement membrane becomes thicker or thinner to induce splitting.
References
- ↑ Bodziak KA, Hammond WS, Molitoris BA (1994). "Inherited diseases of the glomerular basement membrane". Am J Kidney Dis. 23 (4): 605–18. PMID 8154501.
- ↑ Kashtan CE, Michael AF (1993). "Alport syndrome: from bedside to genome to bedside". Am J Kidney Dis. 22 (5): 627–40. PMID 8238007.