Nephrotic syndrome overview: Difference between revisions
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Clinically, nephrotic syndrome is defined as<ref name="pmid18497417">{{cite journal| author=Hull RP, Goldsmith DJ|title=Nephrotic syndrome in adults. | journal=BMJ | year= 2008 | volume= 336 | issue= 7654 | pages= 1185-9 | pmid=18497417 | doi=10.1136/bmj.39576.709711.80 | pmc=PMC2394708 |url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18497417 }} </ref>: | Clinically, nephrotic syndrome is defined as<ref name="pmid18497417">{{cite journal| author=Hull RP, Goldsmith DJ|title=Nephrotic syndrome in adults. | journal=BMJ | year= 2008 | volume= 336 | issue= 7654 | pages= 1185-9 | pmid=18497417 | doi=10.1136/bmj.39576.709711.80 | pmc=PMC2394708 |url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18497417 }} </ref>: | ||
*Heavy proteinuria | *Heavy proteinuria > 3.5 g/24 hrs | ||
*Peripheral edema | *Peripheral edema | ||
*Hypoalbuminemia | *Hypoalbuminemia | ||
*Hyperlipidemia | *Hyperlipidemia and lipiduria | ||
*Hypercoagulability | |||
==Diagnosis== | ==Diagnosis== | ||
Revision as of 08:32, 17 November 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Definition
Nephrotic syndrome (nephrosis) is defined as heavy proteinuria > 3.5 grams per 24 hours in adults. In children, nephrotic syndrome is defined as protein excretion > 40 mg/m2/h. The accurate diagnosis of nephrotic syndrome thus requires 24-hour urine collection. However, in clinical practice, urine dipstick of a qualitative measure of 3+ urinary proteins, or spot urine protein (mg)/creatinine(mg) ratio > 2 may also reflect nephrotic syndrome.[1]
Clinically, nephrotic syndrome is defined as[2]:
- Heavy proteinuria > 3.5 g/24 hrs
- Peripheral edema
- Hypoalbuminemia
- Hyperlipidemia and lipiduria
- Hypercoagulability
Diagnosis
Primary Prevention
Appropriate treatment of conditions that can cause nephrotic syndrome may help prevent the syndrome.
References
- ↑ Kodner C (2009). "Nephrotic syndrome in adults: diagnosis and management". Am Fam Physician. 80 (10): 1129–34. PMID 19904897.
- ↑ Hull RP, Goldsmith DJ (2008). "Nephrotic syndrome in adults". BMJ. 336 (7654): 1185–9. doi:10.1136/bmj.39576.709711.80. PMC 2394708. PMID 18497417.