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Rim Halaby (talk | contribs) (Created page with "{{WBRQuestion |QuestionAuthor={{Rim}} |ExamType=USMLE Step 1 |MainCategory=Microbiology |SubCategory=Infectious Disease |MainCategory=Microbiology |SubCategory=Infectious Dise...") |
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|MainCategory=Microbiology | |MainCategory=Microbiology | ||
|SubCategory=Infectious Disease | |SubCategory=Infectious Disease | ||
|Prompt=Viral hepatitis is a major infectious cause of morbidity and mortality worldwide. Despite being a relatively common disease, prognosis differs greatly depending on the host and the viral type and strain. Which of the following combinations is associated with the highest | |Prompt=Viral hepatitis is a major infectious cause of morbidity and mortality worldwide. Despite being a relatively common disease, prognosis differs greatly depending on the host and the viral type and strain. Which of the following combinations is associated with the highest mortality? | ||
|Explanation=The Hepatitis E virus is a positive-sense single stranded RNA virus transmitted via fecal-oral route. Clinically, hepatitis E is a benign disease often contracted in childhood and is usually asymptomatic. Mortality rates are very low except in patients with severe liver failure. Its course is generally comparable to Hepatitis A except in pregnant women where mortality rates following infection can be as high as 20% particularly in women who contract the virus during their third trimester. | |||
Educational objective: Hepatitis E is associated with increased mortality in pregnant women. | |||
References:<br> | |||
Kumar A, Beniwal M, Kar P, Sharma JB, Murthy NS. Hepatitis E in pregnancy. Int J Gynaecol Obstet. 2004;85(3):240-4. | |||
|AnswerA=Hepatitis A in young children | |AnswerA=Hepatitis A in young children | ||
|AnswerAExp=Hepatitis A in young children is often asymptomatic and rarely carries the risk of associated morbidity and mortality. | |||
|AnswerB=Hepatitis B in elderly patients | |AnswerB=Hepatitis B in elderly patients | ||
|AnswerBExp=Hepatitis B in elderly patients manifests as any acute hepatitis B would except chronicity is more common in elderly patients due to a relatively impaired immunity. | |||
|AnswerC=Hepatitis C in HIV patients | |AnswerC=Hepatitis C in HIV patients | ||
|AnswerD=Hepatitis D in patients with Hepatitis B | |AnswerCExp=Hepatitis C and HIV co-infection is common although increases in mortality have not been documented. | ||
|AnswerD=Hepatitis D in patients with acute Hepatitis B | |||
|AnswerDExp=Hepatitis D can only be acquired in the context of Hepatitis B. Hepatitis D increases mortality significantly in patients with chronic hepatitis B and/or cirrhosis. It usually does not increase mortality as much in patients with acute hepatitis B. | |||
|AnswerE=Hepatitis E in pregnant women | |AnswerE=Hepatitis E in pregnant women | ||
|AnswerEExp=Hepatitis E is associated with high mortality in pregnant women of up to 20%, although it is a benign often asymptomatic disease in the general population. | |||
|RightAnswer=E | |RightAnswer=E | ||
|WBRKeyword=Hepatitis E, pregnant women, Hepatitis, mortality | |WBRKeyword=Hepatitis E, pregnant women, Hepatitis, mortality | ||
|Approved=No | |Approved=No | ||
}} | }} |
Revision as of 07:36, 20 November 2013
Author | [[PageAuthor::Rim Halaby, M.D. [1]]] |
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Exam Type | ExamType::USMLE Step 1 |
Main Category | MainCategory::Microbiology |
Sub Category | SubCategory::Infectious Disease |
Prompt | [[Prompt::Viral hepatitis is a major infectious cause of morbidity and mortality worldwide. Despite being a relatively common disease, prognosis differs greatly depending on the host and the viral type and strain. Which of the following combinations is associated with the highest mortality?]] |
Answer A | AnswerA::Hepatitis A in young children |
Answer A Explanation | AnswerAExp::Hepatitis A in young children is often asymptomatic and rarely carries the risk of associated morbidity and mortality. |
Answer B | AnswerB::Hepatitis B in elderly patients |
Answer B Explanation | AnswerBExp::Hepatitis B in elderly patients manifests as any acute hepatitis B would except chronicity is more common in elderly patients due to a relatively impaired immunity. |
Answer C | AnswerC::Hepatitis C in HIV patients |
Answer C Explanation | AnswerCExp::Hepatitis C and HIV co-infection is common although increases in mortality have not been documented. |
Answer D | AnswerD::Hepatitis D in patients with acute Hepatitis B |
Answer D Explanation | [[AnswerDExp::Hepatitis D can only be acquired in the context of Hepatitis B. Hepatitis D increases mortality significantly in patients with chronic hepatitis B and/or cirrhosis. It usually does not increase mortality as much in patients with acute hepatitis B.]] |
Answer E | AnswerE::Hepatitis E in pregnant women |
Answer E Explanation | AnswerEExp::Hepatitis E is associated with high mortality in pregnant women of up to 20%, although it is a benign often asymptomatic disease in the general population. |
Right Answer | RightAnswer::E |
Explanation | [[Explanation::The Hepatitis E virus is a positive-sense single stranded RNA virus transmitted via fecal-oral route. Clinically, hepatitis E is a benign disease often contracted in childhood and is usually asymptomatic. Mortality rates are very low except in patients with severe liver failure. Its course is generally comparable to Hepatitis A except in pregnant women where mortality rates following infection can be as high as 20% particularly in women who contract the virus during their third trimester.
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Approved | Approved::No |
Keyword | WBRKeyword::Hepatitis E, WBRKeyword::pregnant women, WBRKeyword::Hepatitis, WBRKeyword::mortality |
Linked Question | Linked:: |
Order in Linked Questions | LinkedOrder:: |