Sandbox/68: Difference between revisions
< Sandbox
Gerald Chi (talk | contribs) mNo edit summary |
Gerald Chi (talk | contribs) mNo edit summary |
||
| Line 4: | Line 4: | ||
| align="center" style="background:#f0f0f0;"|'''Functions''' | | align="center" style="background:#f0f0f0;"|'''Functions''' | ||
|- | |- | ||
| Adipose tissue||Adipose-associated macrophages||Control of insulin sensitivity and adaptive thermogenesis | | valign="top" | Adipose tissue | ||
| valign="top" | Adipose-associated macrophages | |||
| valign="top" | Control of insulin sensitivity and adaptive thermogenesis | |||
|- | |- | ||
| Blood ||Ly- | | valign="top" | Blood | ||
| valign="top" | Ly-6C<sup>lo</sup> monocytes | |||
| valign="top" | Function analogously as intravascular housekeepers, clearing endothelial cell debris | |||
|- | |- | ||
| Bone|| | | Bone || Osteoclasts <BR> Bone marrow macrophages ||Multinucleated cells formed by fusion that resorb bone by disruption of the mineralized matrix <BR> Support erythropoeisis and maintain hematopoietic stem cells in stem cell niches" | ||
|- | |- | ||
| Central nervous system||"Microglia | | Central nervous system||"Microglia | ||
Latest revision as of 22:24, 29 November 2013
| Tissue | Cell type | Functions |
| Adipose tissue | Adipose-associated macrophages | Control of insulin sensitivity and adaptive thermogenesis |
| Blood | Ly-6Clo monocytes | Function analogously as intravascular housekeepers, clearing endothelial cell debris |
| Bone | Osteoclasts Bone marrow macrophages |
Multinucleated cells formed by fusion that resorb bone by disruption of the mineralized matrix Support erythropoeisis and maintain hematopoietic stem cells in stem cell niches" |
| Central nervous system | "Microglia | |
| Perivascular macrophages | ||
| Meningeal macrophages" | "Promote neuronal survival and are involved in frontline immune surveillance, removal of dead neurons and synaptic remodelling; derived from yolk sac and maintained in adult and during inflammation independently of the bone marrow | |
| Immune surveillance | ||
| Immune surveillance" | ||
| Gastrointestinal tract | Intestinal macrophages | Maintenance of intestinal homeostasis and regulation of immune responses to commensals; monocyte-derived |
| Liver | "Kupffer cells (sessile) | |
| Motile liver macrophages" | "Clearance of microorganisms and cell debris from the blood, and clearance of aged erythrocytes; prenatal origins; maintained in the adult independently of the bone marrow | |
| Immune surveillance" | ||
| Lung | "Alveolar macrophages | |
| Interstitial macrophages" | "Immune surveillance of the lung for inhaled pathogens and clearance of surfactant; prenatal origins; maintained in adult and during inflammation independently of the bone marrow | |
| Regulates DC maturation and/or activation" | ||
| Serosal tissues | "Peritoneal macrophages | |
| Pleural macrophages" | "Immune surveillance and regulation of homeostatic environment; apoptotic cell clearance; prenatal origins; maintained in adult and during inflammation independently of the bone marrow | |
| Immune surveillance; maintained in adult and can expand during TH2 cell inflammation independently of the bone marrow" | ||
| Skin | "Dermal macrophages | |
| Langerhans cells" | "Immune surveillance | |
| Interaction with T lymphocytes; derived from yolk sac and/or fetal liver and maintained independently of the bone marrow" | ||
| Spleen | "Marginal zone macrophages | |
| Metallophilic macrophages | ||
| Red pulp macrophages | ||
| White pulp (tingible body) macrophages" | "Immune surveillance of the circulation | |
| Immune surveillance | ||
| Erythrocyte clearance and iron metabolism; prenatal origins; maintained in adult independently of the bone marrow | ||
| Clearance of apoptotic cells resulting during the germinal center reaction" |